TSR1

Description		TSR1 ribosome maturation factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding GTPase Activity Protein Binding GTP Binding U3 SnoRNA Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Ribosome Biogenesis
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: BMPR2 CIDEB RHBDD2 SUMO2
Entrez ID		55720
HPRD ID		07681
Ensembl ID		ENSG00000167721
Uniprot IDs		Q2NL82
PDB IDs		6G18 6G4S 6G4W 6G51 6G53 6ZMT 6ZN5 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 8ZDC 8ZDD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Activity Semi-lunar Valve Development Mitral Valve Morphogenesis Lipid Droplet Fusion Signal Recognition Particle Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Axon Extension Involved In Axon Guidance Maternal Placenta Development Lung Vasculature Development Lymphangiogenesis Negative Regulation Of Vasoconstriction Cellular Response To Stress Endocardial Cushion Development Pharyngeal Arch Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Endothelial Cell Apoptotic Process Atrial Septum Morphogenesis Protein Tag Activity COPI-coated Vesicle COPII Vesicle Coat Lipid Transfer Activity Very-low-density Lipoprotein Particle Assembly Regulation Of Cell Proliferation Involved In Heart Morphogenesis COPII-coated Vesicle Cargo Loading Atrioventricular Valve Morphogenesis Response To Nutrient Levels SUMO Transferase Activity BMP Binding Heart Valve Development Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Execution Phase Of Apoptosis Phosphatidic Acid Binding Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Ubiquitin-like Protein Ligase Binding Outflow Tract Septum Morphogenesis
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