CBS and UGP2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CBS	UGP2
Name		cystathionine beta-synthase	UDP-glucose pyrophosphorylase 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Cystathionine Beta-synthase Activity Protein Binding Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding D-glucose Binding Transferase Activity Nucleotidyltransferase Activity Pyrimidine Ribonucleotide Binding Identical Protein Binding Metal Ion Binding UTP-monosaccharide-1-phosphate Uridylyltransferase Activity Uridylyltransferase Activity
	Biological Process	Endochondral Ossification Blood Vessel Remodeling Cysteine Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Superoxide Metabolic Process Amino Acid Biosynthetic Process Serine Family Amino Acid Metabolic Process Regulation Of Nitric Oxide Mediated Signal Transduction Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process Cerebellum Morphogenesis Response To Nutrient Levels DNA Protection Negative Regulation Of Apoptotic Process Homocysteine Catabolic Process Sulfur Compound Biosynthetic Process Regulation Of JNK Cascade Homocysteine Metabolic Process Response To Folic Acid Maternal Process Involved In Female Pregnancy Cartilage Development Involved In Endochondral Bone Morphogenesis Hydrogen Sulfide Biosynthetic Process Cellular Response To Hypoxia Blood Vessel Diameter Maintenance	Glycogen Metabolic Process Glycogen Biosynthetic Process UDP-alpha-D-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Brain Development Energy Derivation By Oxidation Of Organic Compounds Glucose 1-phosphate Metabolic Process
Pathways		Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Formation of the active cofactor, UDP-glucuronate Glycogen synthesis
Drugs		Pyridoxal phosphate Ademetionine Serine Cysteine	None
Diseases		Homocystinuria	None
GWAS		Blood and toenail selenium levels ( 25343990 ) Blood trace element (Se levels) ( 23720494 ) Homocysteine levels ( 20031578 23824729 ) Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 ) Plasma homocysteine levels (post-methionine load test) ( 24651765 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Serum metabolite levels ( 33031748 )	Clozapine-induced agranulocytosis ( 25187353 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Systolic blood pressure ( 26969751 )
Interacting Genes		35 interacting genes: ATRX CBX4 CERT1 DAXX EHHADH FAF1 FXR1 FXR2 HGS HID1 HIPK1 HTT NTAQ1 PAX6 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 SATB1 SLF2 SMARCAD1 SNCA SNRNP70 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5 ZNF181 ZNF451	8 interacting genes: ABCA1 ARIH2 CBS GLRX3 PCBP1 PLEKHF2 TTN UBC
Entrez ID		875	7360
HPRD ID		01994	08934
Ensembl ID		ENSG00000160200	ENSG00000169764
Uniprot IDs		B7Z2D6 P35520	A0A140VKE1 Q16851
PDB IDs		1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS 7QGT 8S5H 8S5I 8S5J 8S5K 8S5L 8S5M 8STW	3R2W 3R3I 4R7P
GO Terms Enriched among Interactors		PML Body Protein Sumoylation SUMO Ligase Activity SUMO Transferase Activity Postsynaptic Cytosol Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Protein Modification Process Transcription Corepressor Activity Phosphoprotein Binding Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Macromolecule Metabolic Process CAMP-dependent Protein Kinase Regulator Activity Nuclear Body Protein Domain Specific Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Iris Morphogenesis Regulation Of Chaperone-mediated Autophagy Glutamatergic Synapse Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Response To Vitamin B3 Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Response To Vitamin Response To Nutrient Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Sequence-specific Single Stranded DNA Binding Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Myosin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Z Disc Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Skeletal Muscle Thin Filament Assembly DNA Protection Modified Amino Acid Binding Viral RNA Genome Replication Detection Of Muscle Stretch Telethonin Binding