CBS and UGP2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CBS	UGP2
Gene Name		cystathionine-beta-synthase	UDP-glucose pyrophosphorylase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytosol Intracellular Membrane-bounded Organelle	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Cystathionine Beta-synthase Activity Protein Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Modified Amino Acid Binding	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding Glucose Binding Pyrimidine Ribonucleotide Binding Metal Ion Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Transsulfuration L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process Homocysteine Catabolic Process Small Molecule Metabolic Process Homocysteine Metabolic Process Hydrogen Sulfide Biosynthetic Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process UDP-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Pathogenesis Glucose 1-phosphate Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation
Pathways		Sulfur amino acid metabolism Metabolism of amino acids and derivatives Cysteine formation from homocysteine	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Glucose metabolism Phase II conjugation Glycogen synthesis Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Glycogen storage diseases Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Metabolism of carbohydrates Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Pyridoxal Phosphate S-Adenosylmethionine L-Serine L-Cysteine Heme
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 20031578) Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: CBX4 COL4A3BP DAXX EHHADH FXR2 HGS HID1 HTT PIAS1 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 UBASH3A UBE2I UGP2 VTA1 ZDHHC17	5 interactors: ABCA1 ARIH2 CBS GLRX3 PCBP1
Entrez ID		875	7360
HPRD ID		01994	08934
Ensembl ID		ENSG00000160200	ENSG00000169764
Uniprot IDs		P35520 Q9NTF0	E7EUC7 Q16851
PDB IDs		1JBQ 1M54 4L0D 4L27 4L28 4L3V	3R2W 3R3I
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Protein Sumoylation Regulation Of Signaling Cell Cycle Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Endosomal Transport Endoplasmic Reticulum Organization Protein Transport Regulation Of Cell Cycle Peptidyl-amino Acid Modification Neural Plate Formation Response To Brefeldin A Positive Regulation Of SUMO Transferase Activity Establishment Of Protein Localization Viral Process Monocarboxylic Acid Metabolic Process Intracellular Transport Response To Stimulus Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Cell Cycle Process Negative Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity ER To Golgi Ceramide Transport Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Positive Regulation Of Ligase Activity Small Molecule Metabolic Process Mitotic Cell Cycle Process Mesoderm Formation Regulation Of Catalytic Activity Negative Regulation Of Signaling Mesoderm Morphogenesis Organelle Organization Regulation Of Ubiquitin-protein Transferase Activity	Cysteine Biosynthetic Process From Serine Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Transsulfuration Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process L-serine Catabolic Process Interleukin-1 Beta Secretion Hydrogen Sulfide Metabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Cysteine Metabolic Process Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Homocysteine Metabolic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Platelet Dense Granule Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Phospholipid Efflux Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Hematopoietic Stem Cell Proliferation Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Membrane Invagination Reverse Cholesterol Transport Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux L-serine Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cdc42 Protein Signal Transduction Regulation Of The Force Of Heart Contraction Protein K63-linked Ubiquitination
Tagcloud ?		catalyze cerevisiae considerably consumed dehydrogenase fermentation flux insufficient lacks metabolically mixtures oxygenation pentose pichia reductase s103 s104 saccharomyces stipitis tal tal1 tkl1 transaldolase transketolase utilization xyl1 xyl2 xylitol xylose	abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr
Tagcloud (Difference) ?		catalyze cerevisiae considerably consumed dehydrogenase fermentation flux insufficient lacks metabolically mixtures oxygenation pentose pichia reductase s103 s104 saccharomyces stipitis tal tal1 tkl1 transaldolase transketolase utilization xyl1 xyl2 xylitol xylose	abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr
Tagcloud (Intersection) ?