CBS and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CBS	EHHADH
Description		cystathionine beta-synthase	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Catalytic Activity Cystathionine Beta-synthase Activity Protein Binding Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Endochondral Ossification Blood Vessel Remodeling Cysteine Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Superoxide Metabolic Process Amino Acid Biosynthetic Process Serine Family Amino Acid Metabolic Process Regulation Of Nitric Oxide Mediated Signal Transduction Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process Cerebellum Morphogenesis Response To Nutrient Levels DNA Protection Negative Regulation Of Apoptotic Process Homocysteine Catabolic Process Sulfur Compound Biosynthetic Process Regulation Of JNK Cascade Homocysteine Metabolic Process Response To Folic Acid Maternal Process Involved In Female Pregnancy Cartilage Development Involved In Endochondral Bone Morphogenesis Hydrogen Sulfide Biosynthetic Process Cellular Response To Hypoxia Blood Vessel Diameter Maintenance	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways		Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs		Pyridoxal phosphate Ademetionine Serine Cysteine	NADH
Diseases		Homocystinuria
GWAS		Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 20031578 23824729) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150) Serum metabolite levels ( 33031748)	Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		35 interacting genes: ATRX CBX4 CERT1 DAXX EHHADH FAF1 FXR1 FXR2 HGS HID1 HIPK1 HTT NTAQ1 PAX6 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 SATB1 SLF2 SMARCAD1 SNCA SNRNP70 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5 ZNF181 ZNF451	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		875	1962
HPRD ID		01994	06125
Ensembl ID		ENSG00000160200	ENSG00000113790
Uniprot IDs		B7Z2D6 P35520	Q08426
PDB IDs		1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS 7QGT 8S5H 8S5I 8S5J 8S5K 8S5L 8S5M 8STW
Enriched GO Terms of Interacting Partners?		PML Body Protein Sumoylation SUMO Ligase Activity SUMO Transferase Activity Postsynaptic Cytosol Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Protein Modification Process Transcription Corepressor Activity Phosphoprotein Binding Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Macromolecule Metabolic Process CAMP-dependent Protein Kinase Regulator Activity Nuclear Body Protein Domain Specific Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Iris Morphogenesis Regulation Of Chaperone-mediated Autophagy Glutamatergic Synapse Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
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