KCNN4 and SLC30A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNN4	SLC30A2
Description		potassium calcium-activated channel subfamily N member 4	solute carrier family 30 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Vesicle Ruffle Membrane Cell Projection Neuron Projection Neuronal Cell Body	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Zymogen Granule Membrane Secretory Vesicle
	Molecular Function	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity Protein Homodimerization Activity	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding Metal Ion Binding Zinc:proton Antiporter Activity
	Biological Process	Immune System Process Monoatomic Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Monoatomic Ion Transmembrane Transport Macropinocytosis Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Transport Protein Homotetramerization Establishment Of Localization In Cell Regulation Of Biological Quality Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Zinc Ion Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Export Across Plasma Membrane Zinc Ion Import Into Secretory Vesicle Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Lysosome Zinc Ion Import Into Mitochondrion
Pathways		Ca2+ activated K+ channels	Zinc efflux and compartmentalization by the SLC30 family
Drugs		Clotrimazole Quinine Procaine Ritodrine Nitrendipine Miconazole Halothane Colforsin Trimebutine
Diseases
GWAS		Breast cancer ( 23535729) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: BIK CACNA1D CALM1 CNIH3 FXYD3 GPR152 JPH3 JPH4 PMP22 PRKAG1 RYR2 SLC30A2 STX1B	67 interacting genes: ABHD16A ADAM33 AQP2 AQP6 ATP13A1 C5orf46 CCL4 CCL4L2 CD40 CD52 CD79A CD99L2 CPLX4 CREB3 CTSA CYB561D2 EBAG9 EMP3 ERGIC3 EVI2B F11R FAM174A FDPS FFAR2 FXYD3 FXYD6 GALNT15 GJA5 GJB2 GJB5 GLB1 GOLT1A GPR161 GPR42 GPRC5D HGFAC KASH5 KCNN4 LMNA LTA LYVE1 MS4A13 NDUFAF1 NRM OPRM1 PCNX2 PLPPR1 PVR SEC22A SELL SERPING1 SLC10A6 SLC16A2 SLC18A1 SLC38A7 SLC39A2 SLC7A1 SLC7A8 TAS2R5 TM4SF18 TMEM107 TMEM52B TMEM60 TMEM86A TNFRSF12A TRARG1 YIPF2
Entrez ID		3783	7780
HPRD ID		04130	18057
Ensembl ID		ENSG00000104783	ENSG00000158014
Uniprot IDs		O15554	Q9BRI3
PDB IDs		6CNM 6CNN 6CNO 6D42
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Metal Ion Transport Calcium Ion Transport Into Cytosol Regulation Of Heart Contraction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Regulation Of Striated Muscle Contraction Regulation Of Blood Circulation Regulation Of System Process Metal Ion Transport Regulation Of Sequestering Of Calcium Ion Regulation Of Calcium Ion Transmembrane Transport Regulation Of Transport Inorganic Ion Transmembrane Transport Calcium-mediated Signaling Membrane Regulation Of Muscle Contraction Junctional Membrane Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Membrane Potential Plasma Membrane Calcium Ion Transport Monoatomic Ion Transport Regulation Of Muscle System Process Detection Of Calcium Ion Inorganic Cation Transmembrane Transport Regulation Of Heart Rate Monoatomic Cation Transmembrane Transport Transmembrane Transport Smooth Endoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cardiac Muscle Cell Action Potential Protein Kinase Binding Cardiac Muscle Cell Action Potential Involved In Contraction Modulation Of Chemical Synaptic Transmission Cardiac Muscle Cell Action Potential Regulation Of Synaptic Plasticity Dendritic Shaft	Membrane Transmembrane Transport Plasma Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Renal Water Transport Gap Junction Assembly Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity CCR1 Chemokine Receptor Binding Amino Acid Import Across Plasma Membrane Amino Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transport Thyroid Hormone Transmembrane Transporter Activity Metal Ion Transport Protein Binding Positive Regulation Of Immune System Process Monoatomic Cation Transport Aromatic Amino Acid Transport
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