CTNNA2 and CTNNBIP1

Number of citations of the paper that reports this interaction (PMID 16325583)
255

Data Source:
HPRD (in vitro)

		CTNNA2	CTNNBIP1
Gene Name		catenin (cadherin-associated protein), alpha 2	catenin, beta interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Adherens Junction Cell-cell Adherens Junction Actin Cytoskeleton Basolateral Plasma Membrane Lamellipodium Axon	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding Beta-catenin Binding Armadillo Repeat Domain Binding
	Biological Process	Axonogenesis Single Organismal Cell-cell Adhesion Radial Glia Guided Migration Of Purkinje Cell Muscle Cell Differentiation Dendrite Morphogenesis Brain Morphogenesis Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Structural Plasticity Prepulse Inhibition	Branching Involved In Ureteric Bud Morphogenesis Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Anterior/posterior Pattern Specification Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Binding Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Mesenchymal Cell Proliferation
Pathways		CDO in myogenesis Myogenesis	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		2 interactors: CTNNBIP1 PTPN14	11 interactors: BEND5 CTNNA2 CTNNB1 EMD INCA1 JUP KRTAP10-3 KRTAP10-7 REL TCF7L2 USHBP1
Entrez ID		1496	56998
HPRD ID		00228	09677
Ensembl ID		ENSG00000066032	ENSG00000178585
Uniprot IDs		P26232 Q49AD3	Q9NSA3
PDB IDs			1LUJ 1M1E 1T08
Enriched GO Terms of Interacting Partners?		Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Monocyte Differentiation Negative Regulation Of Cell Proliferation Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Monocyte Differentiation Regulation Of DNA-templated Transcription, Initiation Lymph Vessel Development Regulation Of Protein Export From Nucleus Regulation Of Vascular Permeability Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of DNA Binding Regulation Of Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Protein Binding Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Osteoblast Differentiation Acute Inflammatory Response Positive Regulation Of Myeloid Cell Differentiation Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of DNA Binding Positive Regulation Of Ossification Renal Tubule Development Negative Regulation Of Binding Regulation Of Smooth Muscle Cell Proliferation Kidney Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Stem Cell Proliferation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Anatomical Structure Morphogenesis Mesonephros Development Regulation Of Osteoblast Differentiation Negative Regulation Of Protein Complex Assembly Nephron Development Regulation Of Protein Binding Kidney Epithelium Development Peptidyl-tyrosine Dephosphorylation Regulation Of Myeloid Cell Differentiation	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Indole-3-methanol Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Muscle Structure Development Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Protein Export From Nucleus Genitalia Morphogenesis Positive Regulation Of Signal Transduction Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Cell Fate Specification Regulation Of Signal Transduction Regulation Of Cell Proliferation Regulation Of Nucleocytoplasmic Transport Skin Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Signaling Positive Regulation Of Intracellular Transport Regulation Of Protein Export From Nucleus Regulation Of Protein Localization Regulation Of Cell Fate Commitment Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Intracellular Protein Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Epithelial Cell-cell Adhesion Regulation Of Oligodendrocyte Differentiation Myoblast Differentiation Adherens Junction Assembly Muscle Cell Differentiation Regulation Of Myelination Positive Regulation Of Protein Transport Positive Regulation Of Stem Cell Differentiation Genitalia Development Regulation Of Cellular Localization Regulation Of Epithelial To Mesenchymal Transition Digestive Tract Morphogenesis Regulation Of Glial Cell Differentiation Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Adherens Junction Organization Response To Organic Substance Canonical Wnt Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Pancreas Development Single Organismal Cell-cell Adhesion Regulation Of Fibroblast Proliferation Regulation Of Gliogenesis
Tagcloud ?		adherens anoikis arid1a cdh1 clustered complexity driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa rnf43 road signatures top
Tagcloud (Difference) ?		adherens anoikis arid1a cdh1 clustered complexity driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa rnf43 road signatures top
Tagcloud (Intersection) ?