FRMD4A and YEATS4

Number of citations of the paper that reports this interaction (PubMedID 22068108)
0

Data Source:
BioGRID (two hybrid)

		FRMD4A	YEATS4
Description		FERM domain containing 4A	YEATS domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Adherens Junction Bicellular Tight Junction Anchoring Junction	Nucleosome Nucleus Nucleoplasm Nuclear Matrix Nuclear Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protein-macromolecule Adaptor Activity	Structural Constituent Of Cytoskeleton Protein Binding Histone Binding Histone H3K18ac Reader Activity Histone H3K27ac Reader Activity
	Biological Process	Negative Regulation Of Protein Secretion Positive Regulation Of Protein Secretion Establishment Of Epithelial Cell Polarity	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways			HATs acetylate histones Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Adiponectin levels ( 26299439) Alcohol consumption (max-drinks) ( 29460428) Alzheimer's disease ( 22430674) Aspartate aminotransferase levels ( 33339817) Basal cell carcinoma ( 33549134) Chronic obstructive pulmonary disease ( 32222710) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Knee osteoarthritis ( 27696742) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obstetric antiphospholipid syndrome ( 28424481) Rapid automised naming of digits ( 30741946) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414 27863252) RR interval (heart rate) ( 20031603) Takayasu arteritis ( 25604533) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)	Complete remission in asthma ( 29786918) Height ( 18391951 31562340) Metabolite levels ( 23823483) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Response to SSRI in MDD or conscientiousness ( 29559929) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		2 interacting genes: TRAF3IP1 YEATS4	16 interacting genes: CEP162 FRMD4A GTF2F2 H3C1 MLLT10 MRGBP MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B TPM1 TRIM54
Entrez ID		55691	8089
HPRD ID		13553	03666
Ensembl ID		ENSG00000151474	ENSG00000127337
Uniprot IDs		Q9NW91 Q9P2Q2	F8W0J4 O95619
PDB IDs			5R68 5R69 5VNA 5VNB 5XTZ 5Y8V 7EIF 7JFY 8DKB 8I60 8IIY 8IIZ 8IJ0 8X15 8X19 8X1C
Enriched GO Terms of Interacting Partners?		Histone H3K27ac Reader Activity Histone H3K18ac Reader Activity Post-anal Tail Morphogenesis Negative Regulation Of Interferon-beta Production Intraciliary Transport Particle B Embryonic Camera-type Eye Development Neural Tube Patterning Negative Regulation Of Defense Response To Virus Intraciliary Anterograde Transport Morphogenesis Of A Polarized Epithelium Embryonic Heart Tube Development NuA4 Histone Acetyltransferase Complex	Nucleoplasm RNA Polymerase II, Holoenzyme Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Epigenetic Regulation Of Gene Expression Cortical Microtubule Spindle Organization Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Protein-containing Complex Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nuclear Receptor Binding Nucleus Localization Nuclear Migration Positive Regulation Of Heart Rate By Epinephrine Positive Regulation Of Double-strand Break Repair Via Homologous Recombination H4/H2A Histone Acetyltransferase Complex Regulation Of DNA Repair Regulation Of Epidermal Cell Differentiation Transcription Factor TFIIF Complex Regulation Of Epidermis Development Establishment Of Organelle Localization Lateral Cell Cortex Positive Regulation Of DNA Metabolic Process Nucleus Chromatin Remodeling Cell Cortex Region Centrosome Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Cerebral Cortex Development Metanephric Nephron Development Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic Spindle Astral Microtubule Microtubule Regulation Of Glucose Mediated Signaling Pathway Mitotic Spindle Organization Distal Tubule Development
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