PACS1 and KLC2

		PACS1	KLC2
Description		phosphofurin acidic cluster sorting protein 1	kinesin light chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Nucleoplasm Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex
	Molecular Function	Protein Binding Transmembrane Transporter Binding	Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Lymphocyte Homeostasis Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane	Microtubule-based Movement Lysosome Localization
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756 33263727 34002096) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4	17 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 LRRK2 MAPK8IP3 PIK3R3 PRC1 RUSC2 S100A8 TRIB1 YWHAG YWHAQ YWHAZ
Entrez ID		55690	64837
HPRD ID		06320	13917
Ensembl ID		ENSG00000175115	ENSG00000174996
Uniprot IDs		Q6VY07	Q9H0B6
PDB IDs			3CEQ 3EDT
Enriched GO Terms of Interacting Partners?		Response To Metal Ion Golgi To Plasma Membrane Transport Trans-Golgi Network Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Liver Development Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Response To Lead Ion Negative Regulation Of DNA Repair Vacuolar Transport Negative Regulation Of Double-strand Break Repair Vesicle-mediated Transport To The Plasma Membrane Response To Calcium Ion Host-mediated Activation Of Viral Process Phosphoprotein Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Transmembrane Transporter Binding Cellular Response To Fluid Shear Stress Metanephric Cortical Collecting Duct Development Response To Fluid Shear Stress Metanephric Cortex Development Metanephric Distal Tubule Development RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Golgi To Plasma Membrane Protein Transport Homocarnosine Synthase Activity Carnosine Synthase Activity Carnosine Biosynthetic Process Kinesin I Complex Tau Protein Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Chloride:proton Antiporter Activity Lysosome Positive Regulation Of Protein Catabolic Process Protein Targeting To Vacuole Rab GDP-dissociation Inhibitor Activity Leading Edge Cell Differentiation Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptidase Activity Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Polycystin Complex Metanephric Smooth Muscle Tissue Development	Kinesin Binding Cytosol Microtubule Binding Growth Cone Transmembrane Transporter Binding Cytoskeletal Motor Activity Cellular Response To Manganese Ion Microtubule-based Movement RAGE Receptor Binding Response To Manganese Ion Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Microtubule-based Process Response To Catecholamine Intracellular Signaling Cassette Regulation Of Synapse Organization Intracellular Signal Transduction Regulation Of Synapse Maturation Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Immune System Process Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Transport Along Microtubule Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Regulation Of CAMP/PKA Signal Transduction Regulation Of Programmed Cell Death Cytoplasm Regulation Of MAPK Cascade Microtubule Vesicle Spindle Pole Kinesin Complex Spindle Microtubule S100A8 Complex Cellular Response To Starvation Regulation Of Protein Stability Protein Sequestering Activity X11-like Protein Binding Signaling Receptor Complex Adaptor Activity Cellular Response To Curcumin Caveola Neck
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