GPRC5D and UNC93B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPRC5D	UNC93B1
Description		G protein-coupled receptor class C group 5 member D	unc-93B1 regulator of TLR signaling
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GO Annotations	Cellular Component	Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Exosome	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Protein Kinase Activator Activity	Protein Binding Toll-like Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways			Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS			Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		30 interacting genes: APOL3 BTN2A2 C14orf180 C1GALT1 CCL4 EMP1 ERMP1 FXYD3 FXYD6-FXYD2 GYPA IFITM3 IGFBP5 LHFPL5 LRRC25 MS4A6A OSMR PMP22 PRRT2 PVR SLC30A2 SLC66A1 SYNDIG1 TMEM120B TMEM19 TMEM208 TMEM79 TRARG1 TWSG1 UNC93B1 YIPF1	31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237
Entrez ID		55507	81622
HPRD ID		07604	12191
Ensembl ID		ENSG00000111291	ENSG00000110057
Uniprot IDs		Q9NZD1	Q9H1C4
PDB IDs		8YZK 9IMA	7C76 7CYN
Enriched GO Terms of Interacting Partners?		Membrane	Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex
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