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UBXN6 and GSK3B
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
UBXN6
GSK3B
Description
UBX domain protein 6
glycogen synthase kinase 3 beta
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Endosome
Centrosome
Cytosol
Cytoskeleton
Membrane
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Plasma Membrane
Membrane
Axon
Dendrite
Beta-catenin Destruction Complex
Presynapse
Postsynapse
Glutamatergic Synapse
Wnt Signalosome
Molecular Function
Protein Binding
ATPase Binding
Nucleotide Binding
Protease Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Beta-catenin Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Dynactin Binding
Tau Protein Binding
Tau-protein Kinase Activity
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Biological Process
Response To Stress
Macroautophagy
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
ERAD Pathway
G1/S Transition Of Mitotic Cell Cycle
Epithelial To Mesenchymal Transition
Positive Regulation Of Cell-matrix Adhesion
Cytoplasmic Translational Initiation
Heart Valve Development
Glycogen Metabolic Process
Protein Phosphorylation
ER Overload Response
Mitochondrion Organization
Regulation Of Mitotic Cell Cycle
Nervous System Development
Circadian Rhythm
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Viral Protein Processing
Hippocampus Development
Establishment Of Cell Polarity
Maintenance Of Cell Polarity
Cell Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Regulation Of Axon Extension
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Neuron Projection Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of TOR Signaling
Positive Regulation Of Protein Binding
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Microtubule-based Process
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Cellular Response To Interleukin-3
TORC2 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Cilium Assembly
Positive Regulation Of Translation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Regulation Of Protein Export From Nucleus
Positive Regulation Of Protein Export From Nucleus
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Microtubule Cytoskeleton Organization
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Superior Temporal Gyrus Development
Cellular Response To Retinoic Acid
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Presynaptic Modulation Of Chemical Synaptic Transmission
Neuron Projection Organization
Membraneless Organelle Assembly
Regulation Of Microtubule Anchoring At Centrosome
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein Localization To Cilium
Negative Regulation Of TORC2 Signaling
Negative Regulation Of Dopaminergic Neuron Differentiation
Cellular Response To Amyloid-beta
Positive Regulation Of Protein Localization To Centrosome
Positive Regulation Of Establishment Of Protein Localization
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Negative Regulation Of Mesenchymal Stem Cell Differentiation
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
Regulation of RUNX2 expression and activity
Maturation of nucleoprotein
Maturation of nucleoprotein
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Transcriptional and post-translational regulation of MITF-M expression and activity
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Lithium cation
3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
SB-409513
AR-AO-14418
Staurosporine
Indirubin-3'-monoxime
6-bromoindirubin-3'-oxime
Alsterpaullone
Phosphoaminophosphonic Acid-Adenylate Ester
2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Fostamatinib
Tideglusib
Lithium citrate
Lithium succinate
Lithium carbonate
Diseases
GWAS
Delta-5 desaturase activity response to n3-polyunsaturated fat supplement (
29246731
)
Multiple sclerosis (
31604244
)
Red blood cell count (
32888494
)
HDL cholesterol (
24097068
)
HDL cholesterol levels (
28334899
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Neutrophil count (
32888494
)
Platelet distribution width (
32888494
)
Serum alkaline phosphatase levels (
33547301
)
Interacting Genes
21 interacting genes:
APP
DAZAP2
DERL1
FAM168A
GSK3B
MAGEA4
MCL1
NLGN3
OGT
PLEKHB2
SMURF1
SUSD6
SVIP
TNFAIP3
TRIM39
UBC
UBXN10
UBXN2A
UBXN2B
VCP
YOD1
245 interacting genes:
ACLY
ACSBG1
ACTL6B
ADAP1
ADIRF
AKAP11
AKT1
AKT2
AKT3
APC
APP
AR
ARRB1
ASRGL1
ATP5IF1
ATXN3
AURKA
AXIN1
AXIN2
BAG6
BCCIP
BCL2A1
BCL2L1
BCL2L12
BCL3
BEX1
BHLHE41
BICD1
BICD2
BRIX1
BTRC
BZW2
C10orf90
C11orf98
CABYR
CAMSAP3
CCND1
CCNE1
CDH1
CDK5
CDX2
CEBPA
CEBPD
CEBPZ
CENPB
CHD3
CIITA
CLEC3B
CMTM2
CREB1
CREB3L3
CREM
CSAD
CSNK2B
CST6
CTNNB1
CTNND1
DBI
DCP1B
DCTN1
DCTN2
DCTN3
DDIT4
DEAF1
DEFA1
DELEC1
DHX34
DISC1
DNAJC13
DNM1L
DNMT1
DNMT3L
DPYSL2
DRC9
DUSP9
DYNC1I1
E2F1
EEF1G
EFTUD2
EIF2B5
EIF4EBP1
ENTPD6
ERG28
EYA1
FAM193B
FAM83D
FBN3
FBXL21P
FBXO7
FBXW11
FEN1
FIBP
FKBP14
FOXO1
FRAT1
FRAT2
FZD5
GBP2
GFI1
GIPC1
GJB5
GOLM2
GPR39
GRIA2
GYS1
HDAC4
HNRNPD
HNRNPM
HSP90AB1
HSPA4
IGHM
IGSF21
IKBKG
ILK
IRF1
JUN
KDM1A
KHSRP
KIAA1191
KIF5B
KLF2
KLF5
LMO4
LPCAT1
LRP6
LUC7L2
LYAR
MAP1B
MAP3K1
MAP3K4
MAP4
MAPK1
MAPT
MARK2
MASP1
MCL1
MDM2
MED24
MEG3
MICAL1
MID1IP1
MITF
MPP1
MTF2
MTOR
MUC1
MYC
MYL6
MYOCD
MYOZ1
NAT9
NBR1
NCOA3
NDRG1
NFE2L1
NFE2L2
NFE2L3
NFKB1
NIN
NOTCH1
NOTCH2
NRBP1
NSFL1C
OGA
OGT
PDE4D
PDPK1
PFKFB4
PHLPP1
PIAS1
PICK1
PIM2
PMAIP1
PPARGC1A
PPP1R2
PRKACA
PRKCA
PRKCB
PRKCZ
PRKDC
PRKRIP1
PSEN1
PSMD8
PTK2
PTN
PTPA
PTPN1
PXN
QARS1
RAI1
RBPJ
RCAN1
RELB
RICTOR
RPL36AL
RPLP1
RPS15
RPS2
RPS6KA1
RSU1
RXRA
SAP30BP
SGK1
SGK3
SLA
SMAD3
SMG7
SNAI1
SNCAIP
SOX10
SPI1
SPTBN4
SREBF1
STAT2
SYNE4
TAFAZZIN
TCAP
TEKT5
TLE1
TMEM132A
TMEM44
TONSL
TP53
TPPP
TRIM72
TSC2
TUBA1A
UBE2D1
UBR1
UBR5
UBXN6
UFM1
UPF3A
VIM
VPS51
XIAP
XPNPEP1
YBX1
YBX3
YWHAZ
ZFPM1
ZHX1
ZNF135
ZNF227
ZNF746
Entrez ID
80700
2932
HPRD ID
18253
05418
Ensembl ID
ENSG00000167671
ENSG00000082701
Uniprot IDs
Q9BZV1
A0A3B3ITW1
P49841
Q6FI27
PDB IDs
6SAP
8FCL
8FCM
8FCN
8FCO
8FCP
8FCQ
8FCR
8FCT
1GNG
1H8F
1I09
1J1B
1J1C
1O6K
1O6L
1O9U
1PYX
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1R0E
1UV5
2JDO
2JDR
2JLD
2O5K
2OW3
2UW9
2X39
2XH5
3CQU
3CQW
3DU8
3E87
3E88
3E8D
3F7Z
3F88
3GB2
3I4B
3L1S
3M1S
3MV5
3OW4
3PUP
3Q3B
3QKK
3QKL
3SAY
3SD0
3ZDI
3ZRK
3ZRL
3ZRM
4ACC
4ACD
4ACG
4ACH
4AFJ
4B7T
4DIT
4EKK
4IQ6
4J1R
4J71
4NM0
4NM3
4NM5
4NM7
4PTC
4PTE
4PTG
5F94
5F95
5HLN
5HLP
5K5N
5KPK
5KPL
5KPM
5OY4
5T31
6B8J
6BUU
6GJO
6GN1
6H0U
6HK3
6HK4
6HK7
6NPZ
6TCU
6V6L
6Y9R
6Y9S
7B6F
7OY5
7SXH
7SXJ
7U2Z
7U31
7U33
7U36
7Z1F
7Z1G
8AUZ
8AV1
8DJC
8DJD
8DJE
8FF8
8QJI
8XN6
Enriched GO Terms of Interacting Partners
?
Regulation Of Proteolysis
Regulation Of Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Proteolysis
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Localization
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Negative Regulation Of Proteolysis
Ubiquitin Protein Ligase Binding
Macromolecule Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Catabolic Process
ERAD Pathway
Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Binding
Regulation Of Protein Modification Process
Response To Endoplasmic Reticulum Stress
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of ERAD Pathway
Catabolic Process
Derlin-1 Retrotranslocation Complex
Regulation Of Extrinsic Apoptotic Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stress
Membrane Assembly
Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Exit From Endoplasmic Reticulum
Regulation Of Protein Localization
Endoplasmic Reticulum Unfolded Protein Response
Protein K11-linked Deubiquitination
Cellular Response To Misfolded Protein
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Cytosol
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cytoplasm
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Cell Communication
Regulation Of Developmental Process
Intracellular Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Developmental Process
Regulation Of Cell Differentiation
Regulation Of Protein Metabolic Process
Regulation Of DNA-templated Transcription
Nucleoplasm
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Intracellular Signal Transduction
Developmental Process
Signal Transduction
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