UBXN6 and MAGEA4

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		UBXN6	MAGEA4
Name		UBX domain protein 6	MAGE family member A4
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Centrosome Cytosol Cytoskeleton Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome	Nucleus
	Molecular Function	Protein Binding ATPase Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Response To Stress Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle
GWAS		Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731 ) Multiple sclerosis ( 31604244 ) Red blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 OGT PLEKHB2 SMURF1 SUSD6 SVIP TNFAIP3 TRIM39 UBC UBXN10 UBXN2A UBXN2B VCP YOD1	27 interacting genes: AMOT AMOTL2 APP ARNT2 BEX2 COX8A GTF3C1 HDDC3 HLA-A LDLRAP1 PICK1 POT1 PSMD10 PUDP RAD18 TEKT4 TIGD5 TK1 TRIM69 TSPYL1 TSPYL4 TXN2 UBXN6 UQCRB UVSSA WBP2 ZNF576
Entrez ID		80700	4103
HPRD ID		18253	02167
Ensembl ID		ENSG00000167671	ENSG00000147381
Uniprot IDs		Q9BZV1	P43358
PDB IDs		6SAP 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT	1I4F 2WA0 6TRN 6TRO 7UOA 8ES8 8ES9 8FJA 9BD3
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process ERAD Pathway Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Regulation Of Protein Modification Process Response To Endoplasmic Reticulum Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of ERAD Pathway Catabolic Process Derlin-1 Retrotranslocation Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Membrane Assembly Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Endoplasmic Reticulum Unfolded Protein Response Protein K11-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway	Establishment Of Cell Polarity Involved In Ameboidal Cell Migration