UBXN6 and SVIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBXN6	SVIP
Description		UBX domain protein 6	small VCP interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Centrosome Cytosol Cytoskeleton Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome	Golgi Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Secretory Granule Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding ATPase Binding	Protein Binding ATPase Binding
	Biological Process	Response To Stress Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway	Positive Regulation Of Autophagy Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Lipidation Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of VCP-NPL4-UFD1 AAA ATPase Complex Assembly Negative Regulation Of ERAD Pathway
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244) Red blood cell count ( 32888494)	Allergic rhinitis ( 25085501) Dialysis-related mortality ( 21546767)
Interacting Genes		21 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 OGT PLEKHB2 SMURF1 SUSD6 SVIP TNFAIP3 TRIM39 UBC UBXN10 UBXN2A UBXN2B VCP YOD1	3 interacting genes: CDR2L UBXN6 VCP
Entrez ID		80700	258010
HPRD ID		18253
Ensembl ID		ENSG00000167671	ENSG00000198168
Uniprot IDs		Q9BZV1	Q8NHG7
PDB IDs		6SAP 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process ERAD Pathway Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Regulation Of Protein Modification Process Response To Endoplasmic Reticulum Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of ERAD Pathway Catabolic Process Derlin-1 Retrotranslocation Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Membrane Assembly Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Endoplasmic Reticulum Unfolded Protein Response Protein K11-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway	Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Endosome To Lysosome Transport ERAD Pathway Flavin Adenine Dinucleotide Catabolic Process Lysosomal Transport VCP-NSFL1C Complex Intracellular Transport Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Macroautophagy Vacuolar Transport Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Golgi To Secretory Granule Transport Response To Endoplasmic Reticulum Stress Cytoplasm Protein Quality Control Endosomal Transport Cellular Localization BAT3 Complex Binding Establishment Of Localization In Cell Positive Regulation Of Protein Deubiquitination Autophagy Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Stress Granule Disassembly Deubiquitinase Activator Activity Protein-DNA Covalent Cross-linking Repair Derlin-1 Retrotranslocation Complex Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Regulation Of Protein Deubiquitination Positive Regulation Of Membrane Potential ATPase Complex Cellular Response To Misfolded Protein Positive Regulation Of Cellular Respiration Response To Misfolded Protein Positive Regulation Of ATP Biosynthetic Process Proteasomal Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Cellular Response To Arsenic-containing Substance MHC Class I Protein Binding Regulation Of ATP Biosynthetic Process Ubiquitin-specific Protease Binding
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