SOX8 and OLIG2

Number of citations of the paper that reports this interaction (PubMedID 16582099)
44

Data Source:
HPRD (in vitro)

		SOX8	OLIG2
Description		SRY-box transcription factor 8	oligodendrocyte transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Positive Regulation Of Gene Expression Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Nervous System Development Sensory Organ Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Oligodendrocyte Cell Fate Specification Thalamus Development Central Nervous System Neuron Differentiation Neuron Differentiation Myelination Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Axon Development
Pathways
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Logical memory (immediate recall) in normal cognition ( 29274321) Multiple sclerosis ( 21833088 31604244) Polycystic ovary syndrome ( 25574032)	Bulimia nervosa ( 23568457) Caffeine consumption from tea ( 33287642) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 31527586) Tea consumption ( 31046077)
Interacting Genes		18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1	16 interacting genes: CKAP5 CUL3 EP300 EXOC7 GOLGA3 HEY1 KRTAP12-4 LRRFIP1 MCF2L2 MRFAP1L1 NAP1L2 NKX2-2 PSMA3 SOX10 SOX8 TXLNA
Entrez ID		30812	10215
HPRD ID		16175	07334
Ensembl ID		ENSG00000005513	ENSG00000205927
Uniprot IDs		P57073	Q13516
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II HMG Box Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Gonadotropin-releasing Hormone Positive Regulation Of Developmental Process Cellular Developmental Process Regulation Of Metabolic Process Developmental Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process System Development CAMP Response Element Binding Nucleus Transcription Regulator Complex Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Host-mediated Activation Of Viral Transcription Positive Regulation Of Canonical Wnt Signaling Pathway Nervous System Development Cell Differentiation Organ Induction Double-stranded DNA Binding	Oligodendrocyte Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Gliogenesis Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Neuron Differentiation Enteric Nervous System Development Regulation Of Gliogenesis Glial Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Chromatin Oligodendrocyte Development Regulation Of Neurogenesis Peripheral Nervous System Development Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Propionylation Swimming Cell Fate Commitment Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Negative Regulation Of DNA-templated Transcription Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Development Histone Crotonyltransferase Activity DNA-binding Transcription Factor Binding Regulation Of Cell Division Response To Progesterone Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Regulation Of Nervous System Development Transcription Elongation By RNA Polymerase II Positive Regulation Of Cytokinesis Microtubule Plus End Polymerase Histone H2B Acetyltransferase Activity Animal Organ Development Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Destabilization Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of TORC1 Signaling Histone Acetyltransferase Regulator Activity Pancreatic A Cell Fate Commitment
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