AQP3 and PLD2

Number of citations: 0 (PubMedID 14675200)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vivo, in vitro)

		AQP3	PLD2
Name		aquaporin 3 (Gill blood group)	phospholipase D2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Brush Border Membrane Presynapse
	Molecular Function	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Channel Activity Identical Protein Binding	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding
	Biological Process	Positive Regulation Of Immune System Process Response To Ischemia Renal Water Homeostasis Water Transport Glycerol Transmembrane Transport Urea Transport Response To Retinoic Acid Response To Vitamin D Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hypoxia Urea Transmembrane Transport	G Protein-coupled Receptor Internalization Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Receptor-mediated Endocytosis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Intracellular Signal Transduction Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vesicle-mediated Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle
Drugs		Bisacodyl Sennosides	Choline Choline salicylate
GWAS		Lung adenocarcinoma ( 28604730 31326317 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 )	Sphingolipid levels ( 22359512 ) Systemic lupus erythematosus ( 26502338 )
Novel Interactors		None recorded	1 novel interactors: TIMM10B
Interacting Genes		28 interacting genes: C14orf180 CD79A ERG28 ERGIC3 EVI2B FAM209A GIMAP5 GPR152 GPX8 HIBADH LEUTX LMNA MFF MGST3 MRM1 MUC1 OLFM4 PLD2 PLP2 SAR1A SGPL1 SSMEM1 STX1A TMEM107 TMEM42 TMEM86A TNF VASN	29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL
Entrez ID		360	5338
HPRD ID		08970	03857
Ensembl ID		ENSG00000165272	ENSG00000129219
Uniprot IDs		A0A2R8Y2R4 B4E034 Q92482	O14939
PDB IDs		Not available	6OHM 6OHO 6OHP 6OHQ 6OHS 7SVP
GO Terms Enriched among Interactors		Membrane	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process T Cell Costimulation Protein Tyrosine Kinase Activity Phospholipase Activator Activity Positive Regulation Of Immune System Process Cytosol Negative Regulation Of Apoptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Phospholipase Binding Cell-cell Junction Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Glycolytic Process Plasma Membrane Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of T Cell Activation Cytoplasm Cellular Response To Oxygen Levels Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Cellular Response To Chemical Stress Fc-gamma Receptor Signaling Pathway Identical Protein Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of ATP Metabolic Process Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cell Development Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone Protein Kinase Binding Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Biological Quality