SYNJ2BP and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 30726710)
43

Data Source:
BioGRID (unspecified method)

		SYNJ2BP	RPS6KA1
Description		synaptojanin 2 binding protein	ribosomal protein S6 kinase A1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Targeting Rho Protein Signal Transduction Regulation Of Notch Signaling Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Endocytosis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Sprouting Angiogenesis	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Purvalanol A Fostamatinib
Diseases
GWAS		Blood pressure ( 24954895) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) LDL cholesterol ( 30275531) Motor coordination ( 34177493) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)
Interacting Genes		34 interacting genes: ACTB ACVR2A ACVR2B APP AQP6 CD79A CPLX4 CREB3L1 CYB561 EBP ELOVL5 ELOVL7 ERGIC3 FAM210B FCER1G LHFPL5 LRP1 LRP2 LRP8 MEDAG RALBP1 REEP4 RPS6KA1 SLC10A6 SLC7A8 SYNJ2 THEM5 TLCD4 TMEM101 TMEM14B TMEM242 UBQLN1 USHBP1 VANGL2	88 interacting genes: ARHGEF11 ARHGEF12 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		55333	6195
HPRD ID		15455	03402
Ensembl ID		ENSG00000213463	ENSG00000117676
Uniprot IDs		P57105	Q15418
PDB IDs		2ENO 2JIK 2JIN 7P73 7P74 7PC9 7R2M 7R2T 8AEL	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV
Enriched GO Terms of Interacting Partners?		Membrane Receptor Complex Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Activin Receptor Activity, Type II Activin Receptor Activity Endocytosis Import Into Cell Astrocyte Activation Involved In Immune Response Cargo Receptor Activity Long-chain Fatty-acyl-CoA Metabolic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Positive Regulation Of Protein Catabolic Process In The Vacuole Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Protein Binding Activin Binding Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Apical Protein Localization Response To Growth Factor Clathrin-coated Pit Vesicle-mediated Transport Plasma Membrane Protein Complex Receptor-mediated Endocytosis Retinoid Metabolic Process Regulation Of Developmental Process Gastrulation With Mouth Forming Second Heparan Sulfate Proteoglycan Binding Astrocyte Activation Transport Across Blood-brain Barrier Diterpenoid Metabolic Process Fatty Acid Derivative Metabolic Process Endoplasmic Reticulum Transcytosis Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Amyloid-beta Clearance Regulation Of Cell Differentiation Acyl-CoA Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress	Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction
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