SYNJ2BP and SYNJ2

Number of citations of the paper that reports this interaction (PubMedID 10357812)
99

Data Source:
HPRD (in vitro, in vivo)

		SYNJ2BP	SYNJ2
Description		synaptojanin 2 binding protein	synaptojanin 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Cell Projection Membrane Raft Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Targeting Rho Protein Signal Transduction Regulation Of Notch Signaling Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Endocytosis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Sprouting Angiogenesis	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Membrane Organization
Pathways			Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood pressure ( 24954895) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) LDL cholesterol ( 30275531) Motor coordination ( 34177493) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Age-related hearing impairment ( 34108613) Cannabis use (initiation) ( 22823124) Gamma glutamyl transferase levels ( 29403010 33339817) Intraocular pressure ( 29617998) Lipoprotein (a) levels ( 26377243) Platelet distribution width ( 32888494)
Interacting Genes		34 interacting genes: ACTB ACVR2A ACVR2B APP AQP6 CD79A CPLX4 CREB3L1 CYB561 EBP ELOVL5 ELOVL7 ERGIC3 FAM210B FCER1G LHFPL5 LRP1 LRP2 LRP8 MEDAG RALBP1 REEP4 RPS6KA1 SLC10A6 SLC7A8 SYNJ2 THEM5 TLCD4 TMEM101 TMEM14B TMEM242 UBQLN1 USHBP1 VANGL2	6 interacting genes: GRB2 ITSN1 ITSN2 NCK1 RAC1 SYNJ2BP
Entrez ID		55333	8871
HPRD ID		15455	10259
Ensembl ID		ENSG00000213463	ENSG00000078269
Uniprot IDs		P57105	A0A1W2PR85 B4DG94 O15056
PDB IDs		2ENO 2JIK 2JIN 7P73 7P74 7PC9 7R2M 7R2T 8AEL	1UFW
Enriched GO Terms of Interacting Partners?		Membrane Receptor Complex Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Activin Receptor Activity, Type II Activin Receptor Activity Endocytosis Import Into Cell Astrocyte Activation Involved In Immune Response Cargo Receptor Activity Long-chain Fatty-acyl-CoA Metabolic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Positive Regulation Of Protein Catabolic Process In The Vacuole Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Protein Binding Activin Binding Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Apical Protein Localization Response To Growth Factor Clathrin-coated Pit Vesicle-mediated Transport Plasma Membrane Protein Complex Receptor-mediated Endocytosis Retinoid Metabolic Process Regulation Of Developmental Process Gastrulation With Mouth Forming Second Heparan Sulfate Proteoglycan Binding Astrocyte Activation Transport Across Blood-brain Barrier Diterpenoid Metabolic Process Fatty Acid Derivative Metabolic Process Endoplasmic Reticulum Transcytosis Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Amyloid-beta Clearance Regulation Of Cell Differentiation Acyl-CoA Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress	Clathrin-dependent Synaptic Vesicle Endocytosis Protein-macromolecule Adaptor Activity Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Endocytosis Regulation Of Actin Filament Length Presynaptic Membrane Intracellular Vesicle Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Receptor-mediated Endocytosis Positive Regulation Of Cytoskeleton Organization Ephrin Receptor Binding Positive Regulation Of Protein-containing Complex Assembly Clathrin-dependent Endocytosis Import Into Cell Regulation Of MAPK Cascade Vesicle Membrane Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Endocytosis Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Lamellipodium Organization Presynaptic Endocytosis Regulation Of Dendritic Spine Development Regulation Of Endocytosis Regulation Of Actin Cytoskeleton Organization Guanyl-nucleotide Exchange Factor Adaptor Activity Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Grb2-EGFR Complex Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Vesicle-mediated Transport In Synapse
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