BRIX1 and UBA2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BRIX1	UBA2
Gene Name		BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	ubiquitin-like modifier activating enzyme 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex
	Molecular Function	Poly(A) RNA Binding	Protein Binding ATP Binding Enzyme Activator Activity Transcription Factor Binding SUMO Activating Enzyme Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Ribosomal Large Subunit Assembly	Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CD48 GSK3B SETDB1 UBA2 UNC119	15 interactors: BRIX1 ETV4 NEDD8 PARK7 RAD23B RANBP2 SAE1 SERBP1 SP100 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBE2I
Entrez ID		55299	10054
HPRD ID		16563	11658
Ensembl ID			ENSG00000126261
Uniprot IDs		Q8TDN6	B3KWB9 Q9UBT2
PDB IDs			1Y8Q 1Y8R 2PX9 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Type B Pancreatic Cell Development SMT3-dependent Protein Catabolic Process Negative Regulation Of Caveolin-mediated Endocytosis Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Cytokinesis, Completion Of Separation Peptidyl-amino Acid Modification Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Response To Interleukin-3 Peptidyl-lysine Modification Regulation Of Neuron Maturation Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Glycogen (starch) Synthase Activity Mitotic Cytokinetic Process Protein Localization To Microtubule Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Histone H3-K9 Trimethylation ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Catalytic Activity Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Cell Separation After Cytokinesis Lipoprotein Transport Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Cellular Ketone Metabolic Process Regulation Of DNA Methylation Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Myoblast Fusion Protein Localization To Cytoskeleton Peptidyl-lysine Trimethylation Protein Sumoylation Blastocyst Growth Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Lithium Ion Regulation Of Cellular Response To Heat	Protein Sumoylation Protein Modification By Small Protein Conjugation Peptidyl-lysine Modification Regulation Of Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Protein Modification Process Regulation Of DNA Binding Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Negative Regulation Of Binding Cellular Macromolecule Catabolic Process Cytokine-mediated Signaling Pathway Protein Localization To Nucleus Proteolysis Regulation Of Protein Export From Nucleus Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Catabolic Process Negative Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i
Tagcloud (Difference) ?			16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i
Tagcloud (Intersection) ?