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BRIX1 and GSK3B
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
BRIX1
GSK3B
Gene Name
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
glycogen synthase kinase 3 beta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Growth Cone
Ribonucleoprotein Complex
Beta-catenin Destruction Complex
Neuronal Cell Body
Dendritic Spine
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Poly(A) RNA Binding
RNA Polymerase II Transcription Factor Binding
P53 Binding
Protein Serine/threonine Kinase Activity
Integrin Binding
Protein Binding
ATP Binding
Beta-catenin Binding
Kinase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Ionotropic Glutamate Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
NF-kappaB Binding
Biological Process
Ribosomal Large Subunit Assembly
Re-entry Into Mitotic Cell Cycle
Epithelial To Mesenchymal Transition
Positive Regulation Of Cell-matrix Adhesion
Glycogen Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Protein Phosphorylation
Protein Export From Nucleus
ER Overload Response
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Myoblast Fusion
Circadian Rhythm
Fibroblast Growth Factor Receptor Signaling Pathway
Organ Morphogenesis
Response To Lithium Ion
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Neuron Maturation
Cell Migration
Peptidyl-serine Phosphorylation
Hippocampus Development
Establishment Of Cell Polarity
Negative Regulation Of Protein Complex Assembly
Positive Regulation Of Protein Complex Assembly
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Rac GTPase Activity
Regulation Of Microtubule-based Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Heat
Protein Localization To Microtubule
Intracellular Signal Transduction
Cellular Response To Interleukin-3
Fc-epsilon Receptor Signaling Pathway
Response To Drug
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Hypermethylation Of CpG Island
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Innate Immune Response
Fat Cell Differentiation
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Protein Export From Nucleus
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Regulation Of Neuronal Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Negative Regulation Of NFAT Protein Import Into Nucleus
Canonical Wnt Signaling Pathway
Superior Temporal Gyrus Development
Cellular Response To Mechanical Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Cellular Response To Heat
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Stem Cell Differentiation
Pathways
Signaling by the B Cell Receptor (BCR)
Hedgehog 'off' state
Signaling by FGFR in disease
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
AKT phosphorylates targets in the cytosol
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
PI3K/AKT activation
PI-3K cascade
RNF mutants show enhanced WNT signaling and proliferation
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
CRMPs in Sema3A signaling
Adaptive Immune System
Axon guidance
PIP3 activates AKT signaling
APC truncation mutants have impaired AXIN binding
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
XAV939 inhibits tankyrase, stabilizing AXIN
Innate Immune System
Signalling by NGF
Semaphorin interactions
Signaling by Ligand-Responsive EGFR Variants in Cancer
Regulation of HSF1-mediated heat shock response
Cellular response to heat stress
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
TCF dependent signaling in response to WNT
Signaling by Hedgehog
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Lithium
3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
I-5
N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
Staurosporine
Indirubin-3\'-Monoxime
Adenosine-5\'-Diphosphate
(3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime
Alsterpaullone
Phosphoaminophosphonic Acid-Adenylate Ester
2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
CD48
GSK3B
SETDB1
UBA2
UNC119
206 interactors:
ACLY
ACSBG1
ACTL6B
ADAP1
ADIRF
AKAP11
AKT1
AKT2
AKT3
APC
APP
AR
ARRB1
ASRGL1
ATPIF1
ATXN3
AURKA
AXIN1
AXIN2
BAG6
BCL3
BEX1
BICD1
BICD2
BRIX1
BTRC
BZW2
C14orf1
CABYR
CAMSAP3
CCND1
CCNE1
CDH1
CDK5
CDX2
CEBPA
CEBPZ
CENPB
CHD3
CIITA
CLEC3B
CREB1
CREM
CSAD
CST6
CTNNB1
CTNND1
DBI
DCTN1
DCTN2
DCTN3
DDIT4
DEAF1
DEFA1
DHX34
DNAJC13
DNM1L
DNMT1
DNMT3L
DPYSL2
DUSP9
DYNC1I1
E2F1
EEF1A1
EEF1G
EFTUD2
EIF2B5
EIF4EBP1
ENTPD6
EYA1
FAM193B
FAM83D
FBN3
FEN1
FIBP
FKBP14
FOXO1
FRAT1
FRAT2
FZD5
GAPDH
GBP2
GIPC1
GJB5
GNB2
GPR39
GYS1
HDAC4
HNRNPD
HSP90AA1
HSPA4
IGHM
IGSF21
IKBKG
ILK
IQCG
JUN
KHSRP
KIAA1191
KIF5B
KLF2
KLF5
LMO4
LRP6
LUC7L2
MAP1B
MAP3K1
MAP3K4
MAP4
MAPK1
MAPT
MARK2
MASP1
MCL1
MDM2
MED24
MGEA5
MICAL1
MID1IP1
MITF
MPP1
MTF2
MTOR
MUC1
MYC
MYOCD
NAT9
NBR1
NCOA3
NFE2L1
NFE2L2
NFKB1
NIN
NOTCH1
NOTCH2
NRBP1
NSFL1C
OGT
PDE4D
PFKFB4
PHLPP1
PIK3R1
PIM2
PMAIP1
PPARGC1A
PPP1R2
PRKACA
PRKCA
PRKCB
PRKCZ
PRKDC
PSEN1
PTK2
PTN
PTPN1
PXN
QARS
RAI1
RBPJ
RCAN1
RELB
RICTOR
RPL36AL
RPLP1
RPS2
RPS6KA1
RSU1
RXRA
SAP30BP
SGK1
SGK3
SLA
SMAD1
SMAD3
SNAI1
SNCA
SNCAIP
SPTBN4
SREBF1
SYNE4
TAZ
TLE1
TMEM132A
TMEM44
TONSL
TP53
TPPP
TSC2
TUBA1A
UBE2D1
UBR1
UBR5
UBXN6
UFM1
UPF3A
VIM
VPS51
WSB1
XPNPEP1
YBX1
YBX3
ZFPM1
ZHX1
ZNF135
ZNF227
ZNF746
Entrez ID
55299
2932
HPRD ID
16563
05418
Ensembl ID
ENSG00000082701
Uniprot IDs
Q8TDN6
P49841
Q6FI27
PDB IDs
1GNG
1H8F
1I09
1J1B
1J1C
1O6K
1O6L
1O9U
1PYX
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1R0E
1UV5
2JDO
2JDR
2JLD
2O5K
2OW3
2UW9
2X39
2XH5
3CQU
3CQW
3DU8
3E87
3E88
3E8D
3F7Z
3F88
3GB2
3I4B
3L1S
3M1S
3PUP
3Q3B
3SAY
3SD0
3ZDI
3ZRK
3ZRL
3ZRM
4ACC
4ACD
4ACG
4ACH
4AFJ
4B7T
4DIT
4EKK
4IQ6
4J1R
4J71
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Clathrin-mediated Endocytosis
Negative Regulation Of Type B Pancreatic Cell Development
SMT3-dependent Protein Catabolic Process
Negative Regulation Of Caveolin-mediated Endocytosis
Superior Temporal Gyrus Development
Re-entry Into Mitotic Cell Cycle
Negative Regulation Of Neuron Maturation
Cytokinesis, Completion Of Separation
Peptidyl-amino Acid Modification
Hypermethylation Of CpG Island
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Cellular Response To Interleukin-3
Peptidyl-lysine Modification
Regulation Of Neuron Maturation
Regulation Of Caveolin-mediated Endocytosis
Negative Regulation Of Glycogen (starch) Synthase Activity
Mitotic Cytokinetic Process
Protein Localization To Microtubule
Negative Regulation Of Dendrite Morphogenesis
Negative Regulation Of NFAT Protein Import Into Nucleus
Histone H3-K9 Trimethylation
ER Overload Response
Negative Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Muscle Hypertrophy
Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Clathrin-mediated Endocytosis
Positive Regulation Of Catalytic Activity
Negative Regulation Of Transport
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Protein Export From Nucleus
Regulation Of Type B Pancreatic Cell Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Dendrite Development
Cell Separation After Cytokinesis
Lipoprotein Transport
Negative Regulation Of Receptor-mediated Endocytosis
Regulation Of Cellular Ketone Metabolic Process
Regulation Of DNA Methylation
Histone H3-K9 Methylation
Inner Cell Mass Cell Proliferation
Myoblast Fusion
Protein Localization To Cytoskeleton
Peptidyl-lysine Trimethylation
Protein Sumoylation
Blastocyst Growth
Regulation Of Gene Expression By Genetic Imprinting
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Lithium Ion
Regulation Of Cellular Response To Heat
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Protein Metabolic Process
Response To Organic Substance
Cellular Response To Organic Substance
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Protein Metabolic Process
Regulation Of Signaling
Regulation Of Gene Expression
Response To Stress
Cellular Response To Stimulus
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Regulation Of Signal Transduction
Apoptotic Process
Negative Regulation Of Biosynthetic Process
Developmental Process
Negative Regulation Of Protein Metabolic Process
Cell Death
Death
Programmed Cell Death
Regulation Of Cell Differentiation
Anatomical Structure Development
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Death
Gene Expression
Multicellular Organismal Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Negative Regulation Of Transcription, DNA-templated
Cell Differentiation
Posttranscriptional Regulation Of Gene Expression
Tagcloud
?
200mg
clamp
coagulation
confirmation
dm
downregulated
encountered
f3
gskbeta3
hg
hi
hour
hyperglycemia
hyperinsulinemia
ingenuity
monocyte
monocytes
pik3c3
platelet
platelets
proinflammatory
prothrombotic
ptpn1
ptpn11
qrt
stxbp4
tf
tfpi
thrombin
Tagcloud (Difference)
?
200mg
clamp
coagulation
confirmation
dm
downregulated
encountered
f3
gskbeta3
hg
hi
hour
hyperglycemia
hyperinsulinemia
ingenuity
monocyte
monocytes
pik3c3
platelet
platelets
proinflammatory
prothrombotic
ptpn1
ptpn11
qrt
stxbp4
tf
tfpi
thrombin
Tagcloud (Intersection)
?