DTD1 and CDC7

Number of citations: 47 (PubMedID 25258324)
Data Source: BioGRID (enzymatic study)

		DTD1	CDC7
Name		D-aminoacyl-tRNA deacylase 1	cell division cycle 7
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	TRNA Binding Aminoacyl-tRNA Deacylase Activity DNA Binding RNA Binding Hydrolase Activity Metal Ion Binding D-aminoacyl-tRNA Deacylase Activity D-tyrosyl-tRNA(Tyr) Deacylase Activity Gly-tRNA(Ala) Deacylase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	DNA Replication TRNA Metabolic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Division
Pathways		None	Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
GWAS		Alcohol consumption (drinks per week) ( 30679032 ) Anxiety ( 33859377 ) Bitter alcoholic beverage consumption ( 31046077 ) C-reactive protein (red blood cell fatty acid level interaction) ( 28820441 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 )	Eosinophil percentage of white cells ( 27863252 ) Gestational age at birth (maternal effect) ( 28877031 ) Glaucoma (primary open-angle) ( 33627673 25861811 ) Lung function (FEV1/FVC) ( 28166213 ) Lung function (FVC) ( 26635082 ) Optic disc area ( 21307088 31798171 28073927 25631615 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Plateletcrit ( 32888494 ) PR interval ( 32439900 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Vertical cup-disc ratio ( 28073927 25241763 31798171 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		4 interacting genes: CDC7 CSNK2A1 NR3C1 PTPA	52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B
Entrez ID		92675	8317
HPRD ID		13631	10345
Ensembl ID		ENSG00000125821	ENSG00000097046
Uniprot IDs		A0A2R8Y6X2 Q8TEA8	A0A384MTU6 B2R6V2 O00311
PDB IDs		2OKV	4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8
GO Terms Enriched among Interactors		Hsp90 Protein Binding Recombinational Repair Double-strand Break Repair Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Double-strand Break Repair Via Homologous Recombination DNA Recombination Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Nuclear Glucocorticoid Receptor Activity Protein Tyrosine Phosphatase Activator Activity Aggrephagy Nucleotide Binding ATP Binding Regulation Of Programmed Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Apoptotic Process Protein Serine Kinase Activity Nucleoplasm Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Serine/threonine Kinase Activity Regulation Of Glucocorticoid Biosynthetic Process Neuroinflammatory Response Response To Cortisol Regulation Of Glucocorticoid Metabolic Process Mammary Gland Duct Morphogenesis Microglia Differentiation Estrogen Response Element Binding Steroid Hormone Binding Maternal Behavior Regulation Of Steroid Hormone Biosynthetic Process Parental Behavior Glucocorticoid Metabolic Process Phosphatase Activator Activity Protein Phosphatase Type 2A Complex ATPase Complex Double-strand Break Repair Via Break-induced Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of DNA-templated DNA Replication MRNA Methylguanosine-cap Decapping Regulation Of Cell Cycle Phase Transition Cell Division Core Promoter Sequence-specific DNA Binding Regulation Of DNA Metabolic Process Sin3-type Complex Protein Kinase Activity DNA Repair	DNA Replication Initiation DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region DNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Replication Origin Binding Single-stranded DNA Helicase Activity Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Single-stranded DNA Binding Mitotic DNA Replication Initiation Regulation Of Metabolic Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Repair Double-strand Break Repair Via Homologous Recombination DNA Damage Response Recombinational Repair DNA Helicase Activity Positive Regulation Of DNA Replication Dbf4-dependent Protein Kinase Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Mitotic Cell Cycle DNA Strand Elongation Mesoderm Development Chromatin Organization Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity