JUNB and USP24

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		JUNB	USP24
Description		JunB proto-oncogene, AP-1 transcription factor subunit	ubiquitin specific peptidase 24
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Trophectodermal Cell Differentiation Osteoclast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Osteoclast Differentiation Osteoblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Response To Steroid Hormone Regulation Of Cell Cycle Embryonic Process Involved In Female Pregnancy Labyrinthine Layer Blood Vessel Development Cellular Response To Calcium Ion Integrated Stress Response Signaling Regulation Of T-helper 17 Cell Differentiation	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Interleukin-4 and Interleukin-13 signaling NGF-stimulated transcription NGF-stimulated transcription Nuclear events stimulated by ALK signaling in cancer	Ub-specific processing proteases
Drugs
Diseases
GWAS			Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) LDL levels x fish oil supplementation interaction (2df) ( 33760818) Metabolite levels ( 22916037) Methadone dose in opioid dependence ( 28115739) Total cholesterol levels x fish oil supplementation interaction (2df) ( 33760818) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		39 interacting genes: APLP2 ATF4 BATF BATF2 BCL6 BDNF BRCA1 DDIT3 DNMT3L EP300 ESR1 FOS FOSB FOSL1 FOSL2 HOXA7 ITCH JDP2 MAP2 MAPK14 MAPK6 MAPK8 MAPK9 NEU1 NFE2L1 NINL PKIA SAT1 SET SMAD3 SMAD4 SMURF1 TCERG1 TDG UBA6 UBE2I USP24 ZNF595 ZSWIM9	6 interacting genes: CSNK2A1 DDB2 JUNB RUNX2 TP53 UBC
Entrez ID		3726	23358
HPRD ID		01303	11664
Ensembl ID		ENSG00000171223	ENSG00000162402
Uniprot IDs		P17275 Q5U079	Q9UPU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Chromatin Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signaling Cassette Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II MAP Kinase Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stem Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II R-SMAD Binding Sequence-specific Double-stranded DNA Binding Regulation Of Metabolic Process Promoter-specific Chromatin Binding	Transcription Regulator Complex Leukocyte Differentiation Ligamentous Ossification Osteoblast Differentiation Tissue Development Nucleoplasm Stem Cell Proliferation Regulation Of Stem Cell Proliferation Stem Cell Differentiation Regulation Of Cell Population Proliferation Osteoblast Fate Commitment T Cell Differentiation Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Cell Population Proliferation Negative Regulation Of DNA Metabolic Process Negative Regulation Of Proteolysis Protein Kinase CK2 Complex Cellular Response To Stress Symbiont-mediated Disruption Of Host Cell PML Body Macroautophagy DNA Repair Regulation Of Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling PML Body Nucleotide-excision Repair Response To UV Cellular Response To UV Cellular Response To Light Stimulus Leukocyte Proliferation Embryonic Organ Development Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Intracellular Signal Transduction
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