JUNB and TDG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		JUNB	TDG
Description		JunB proto-oncogene, AP-1 transcription factor subunit	thymine DNA glycosylase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Plasma Membrane PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Transcription Coregulator Activity Uracil DNA N-glycosylase Activity Protein Kinase C Binding Protein Binding ATP Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding G/U Mismatch-specific Uracil-DNA Glycosylase Activity DNA-binding Transcription Factor Binding G/T Mismatch-specific Thymine-DNA Glycosylase Activity
	Biological Process	Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Trophectodermal Cell Differentiation Osteoclast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Osteoclast Differentiation Osteoblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Response To Steroid Hormone Regulation Of Cell Cycle Embryonic Process Involved In Female Pregnancy Labyrinthine Layer Blood Vessel Development Cellular Response To Calcium Ion Integrated Stress Response Signaling Regulation Of T-helper 17 Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Chromatin Organization DNA Damage Response Epigenetic Regulation Of Gene Expression Depyrimidination Regulation Of Embryonic Development Chromosomal 5-methylcytosine DNA Demethylation, Oxidation Pathway
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Interleukin-4 and Interleukin-13 signaling NGF-stimulated transcription NGF-stimulated transcription Nuclear events stimulated by ALK signaling in cancer	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS			Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)
Interacting Genes		39 interacting genes: APLP2 ATF4 BATF BATF2 BCL6 BDNF BRCA1 DDIT3 DNMT3L EP300 ESR1 FOS FOSB FOSL1 FOSL2 HOXA7 ITCH JDP2 MAP2 MAPK14 MAPK6 MAPK8 MAPK9 NEU1 NFE2L1 NINL PKIA SAT1 SET SMAD3 SMAD4 SMURF1 TCERG1 TDG UBA6 UBE2I USP24 ZNF595 ZSWIM9	38 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD51 RAD9A RXRA SERBP1 SETX SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC
Entrez ID		3726	6996
HPRD ID		01303	03251
Ensembl ID		ENSG00000171223	ENSG00000139372
Uniprot IDs		P17275 Q5U079	B4DI29 B4E127 G8JL98 Q13569
PDB IDs			1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Chromatin Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signaling Cassette Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II MAP Kinase Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stem Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II R-SMAD Binding Sequence-specific Double-stranded DNA Binding Regulation Of Metabolic Process Promoter-specific Chromatin Binding	Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Enzyme Binding Regulation Of Macromolecule Metabolic Process DNA Damage Response Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Transcription Regulator Complex Damaged DNA Binding Rhythmic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Reproductive Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Hormone-mediated Signaling Pathway Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Transcription Coactivator Binding Response To UV Response To Radiation
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