AKAP9 and CCDC146

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AKAP9	CCDC146
Description		A-kinase anchoring protein 9	coiled-coil domain containing 146
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Cytoplasm Centrosome Centriole Cytoskeleton Cilium Axoneme Midbody Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Sperm Head-tail Coupling Apparatus
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity Potassium Channel Activator Activity	Protein Binding Protein-containing Complex Binding
	Biological Process	Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Golgi Organization	Cell Morphogenesis Nucleus Organization Spermatogenesis Spermatid Development Sperm Axoneme Assembly Single Fertilization Cell Population Proliferation Gene Expression Cell Differentiation Flagellated Sperm Motility Cilium Organization Sperm Flagellum Assembly Manchette Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Appendicular lean mass ( 33097823) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)	Amyloid beta positivity ( 34154648) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Macrovascular complications in type 2 diabetes ( 33430853) Ophthalmic complications in type 2 diabetes ( 33430853) Response to amphetamines ( 22952603)
Interacting Genes		85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE	71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 CFTR DRC4 DTNBP1 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52
Entrez ID		10142	57639
HPRD ID		04921	11150
Ensembl ID		ENSG00000127914	ENSG00000135205
Uniprot IDs		A0A2R8Y590 Q5GIA7 Q6PJH3 Q99996	Q8IYE0 Q96MS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Cytoskeleton Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transporter Activity Cytoplasm Centrosome Nucleus Microtubule Nucleation Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Adenylate Cyclase Activator Activity Negative Regulation Of Calcium Ion Transmembrane Transport Protein Binding Negative Regulation Of Transmembrane Transport Spindle Microtubule Transporter Inhibitor Activity Microtubule-based Process Regulation Of Cardiac Muscle Contraction Regulation Of Cytokinesis Regulation Of Cell Cycle Transmembrane Transporter Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport Nucleoplasm Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Metal Ion Transport Regulation Of Action Potential Regulation Of Striated Muscle Contraction Microtubule Cytoskeleton Organization Regulation Of Calcium Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Domain Specific Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ubiquitin Protein Ligase Binding Spindle Titin Binding Calcium Channel Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Regulation Of Transmembrane Transporter Activity	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Cytoskeleton Structural Molecule Activity Organelle Organization Supramolecular Fiber Organization Epithelial Cell Differentiation Microtubule-based Process Protein Binding Morphogenesis Of An Epithelium Centrosome Cycle Tissue Morphogenesis Microtubule Nucleation Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Microtubule Binding Vesicle Transport Along Microtubule
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