AKAP9 and GTSE1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		AKAP9	GTSE1
Description		A-kinase anchoring protein 9	G2 and S-phase expressed 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity Potassium Channel Activator Activity	Protein Binding Microtubule Binding
	Biological Process	Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Golgi Organization	Microtubule-based Process DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2	G2/M Checkpoints The role of GTSE1 in G2/M progression after G2 checkpoint
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Appendicular lean mass ( 33097823) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)
Interacting Genes		85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE	22 interacting genes: AKAP9 CASK CPSF7 CTTN FXR2 GGA1 HNRNPD KAT5 KIFAP3 MAPRE1 MAPRE2 MAPRE3 NIN PHF5A PPIE PRPF39 RBM10 TRNAU1AP UBC WDR83 WEE2-AS1 WTAP
Entrez ID		10142	51512
HPRD ID		04921	09593
Ensembl ID		ENSG00000127914	ENSG00000075218
Uniprot IDs		A0A2R8Y590 Q5GIA7 Q6PJH3 Q99996	Q9NYZ3
PDB IDs			6QNN 6QNP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Cytoskeleton Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transporter Activity Cytoplasm Centrosome Nucleus Microtubule Nucleation Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Adenylate Cyclase Activator Activity Negative Regulation Of Calcium Ion Transmembrane Transport Protein Binding Negative Regulation Of Transmembrane Transport Spindle Microtubule Transporter Inhibitor Activity Microtubule-based Process Regulation Of Cardiac Muscle Contraction Regulation Of Cytokinesis Regulation Of Cell Cycle Transmembrane Transporter Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport Nucleoplasm Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Metal Ion Transport Regulation Of Action Potential Regulation Of Striated Muscle Contraction Microtubule Cytoskeleton Organization Regulation Of Calcium Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Domain Specific Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ubiquitin Protein Ligase Binding Spindle Titin Binding Calcium Channel Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Regulation Of Transmembrane Transporter Activity	MRNA Processing Protein Localization To Microtubule Cytoplasmic Microtubule RNA Splicing Microtubule Plus-end Microtubule Plus-end Binding Spindle Midzone Mitotic Spindle Astral Microtubule End RNA Processing MRNA Metabolic Process Microtubule Organizing Center Regulation Of Microtubule Polymerization Or Depolymerization Pre-mRNA 5'-splice Site Binding Mitotic Spindle Pole Microtubule Cytoskeleton Organization Protein Localization To Cytoskeleton Microtubule-based Process MRNA 5'-splice Site Recognition Positive Regulation Of Cellular Component Organization Regulation Of Microtubule Cytoskeleton Organization RNA Binding Nucleic Acid Binding Regulation Of Microtubule Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cytoskeleton Organization Positive Regulation Of Protein Polymerization Intracellular Protein Localization RNA Metabolic Process Spindle Assembly Muscle Cell Apoptotic Process U1 SnRNP MRNA Binding Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Regulation Of Microtubule-based Process Cellular Component Assembly Positive Regulation Of Organelle Organization Membraneless Organelle Assembly Protein Serine/threonine Kinase Binding Regulation Of Cytoskeleton Organization Nucleic Acid Metabolic Process Regulation Of Organelle Organization Nucleobase-containing Compound Metabolic Process Microtubule Nucleation Regulation Of MRNA Metabolic Process Positive Regulation Of Microtubule Polymerization Centrosome Localization MRNA Splice Site Recognition Microtubule
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