GOLPH3L and C1GALT1

Number of citations of the paper that reports this interaction (PubMedID 34473204)
68

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GOLPH3L	C1GALT1
Description		golgi phosphoprotein 3 like	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cytosol Membrane Golgi Cisterna Golgi Cisterna Membrane Trans-Golgi Network Membrane	Golgi Membrane Membrane
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-4-phosphate Binding Cargo Adaptor Activity	Nucleotide Binding Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Golgi To Plasma Membrane Protein Transport Golgi Vesicle Budding Positive Regulation Of Protein Secretion Protein Targeting To Golgi Apparatus	Angiogenesis Kidney Development Protein Glycosylation Protein O-linked Glycosylation Cell Differentiation Intestinal Epithelial Cell Development
Pathways			Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronotype ( 30696823) Keratinocyte cancer (MTAG) ( 31174203) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 25217961) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Triglyceride levels ( 32203549) Urate levels ( 31578528)	Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		26 interacting genes: ARL6IP1 B4GALT4 C1GALT1 CANT1 DIPK2A EBAG9 EXT1 FAM20B FAM3C GALNT2 GALNT6 GALNT7 GCNT1 GLG1 GLT8D1 GOLIM4 GOLM2 HTT LNX1 MAN1B1 MGAT2 PGAP4 POMGNT1 TPST1 TPST2 ZDHHC17	35 interacting genes: ANKS6 AQP6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GOLPH3 GOLPH3L GPR101 GPR151 GPR42 GPRC5D GPX8 LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC18A1 SLC1A1 SLC35H1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B XRN1
Entrez ID		55204	56913
HPRD ID		17048	16631
Ensembl ID		ENSG00000143457	ENSG00000106392
Uniprot IDs		Q9H4A5	A0A024RA32 Q9NS00
PDB IDs
Enriched GO Terms of Interacting Partners?		Golgi Apparatus Golgi Membrane Glycoprotein Metabolic Process Glycosyltransferase Activity Glycoprotein Biosynthetic Process Protein Glycosylation Macromolecule Glycosylation Glycosylation Carbohydrate Derivative Metabolic Process Carbohydrate Derivative Biosynthetic Process Protein O-linked Glycosylation Transferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein Modification Process Protein Metabolic Process Macromolecule Biosynthetic Process Polypeptide N-acetylgalactosaminyltransferase Activity Membrane Proteoglycan Biosynthetic Process Protein-tyrosine Sulfotransferase Activity Carbohydrate Binding Proteoglycan Metabolic Process Macromolecule Metabolic Process Manganese Ion Binding Golgi Cisterna Membrane 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Carbohydrate Metabolic Process Sulfation Acetylglucosaminyltransferase Activity UDP-glycosyltransferase Activity Leukocyte Tethering Or Rolling Golgi Lumen Leukocyte Adhesion To Vascular Endothelial Cell Viral Protein Processing Basement Membrane Organization Bone Morphogenesis Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Peptidyl-tyrosine Sulfation Perforant Pathway To Dendrate Granule Cell Synapse Golgi Stack N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Trans-Golgi Network Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity	Membrane Gap Junction Channel Activity Connexin Complex Protein Targeting To Golgi Apparatus Gap Junction Golgi Vesicle Budding Cargo Adaptor Activity Neurotransmitter Transport Plasma Membrane Transmembrane Transport Monoatomic Anion Channel Activity Protein Binding Golgi Cisterna Protein Localization To Membrane
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