GOLPH3L and MAN1B1

Number of citations of the paper that reports this interaction (PubMedID 34473204)
68

Data Source:
BioGRID (pull down)

		GOLPH3L	MAN1B1
Description		golgi phosphoprotein 3 like	mannosidase alpha class 1B member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cytosol Membrane Golgi Cisterna Golgi Cisterna Membrane Trans-Golgi Network Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Endoplasmic Reticulum Quality Control Compartment Extracellular Vesicle
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-4-phosphate Binding Cargo Adaptor Activity	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Metal Ion Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Golgi To Plasma Membrane Protein Transport Golgi Vesicle Budding Positive Regulation Of Protein Secretion Protein Targeting To Golgi Apparatus	Carbohydrate Metabolic Process Protein Glycosylation Glycoprotein Metabolic Process Oligosaccharide Metabolic Process Viral Protein Processing ERAD Pathway Protein Alpha-1,2-demannosylation Endoplasmic Reticulum Mannose Trimming
Pathways			Defective MAN1B1 causes MRT15 ER Quality Control Compartment (ERQC) Maturation of spike protein
Drugs			1,4-Butanediol Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside Kifunensine Duvoglustat
Diseases
GWAS		Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronotype ( 30696823) Keratinocyte cancer (MTAG) ( 31174203) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 25217961) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Triglyceride levels ( 32203549) Urate levels ( 31578528)	Coronary artery aneurysm in Kawasaki disease ( 33772158) Initial alcohol sensitivity ( 30276832)
Interacting Genes		26 interacting genes: ARL6IP1 B4GALT4 C1GALT1 CANT1 DIPK2A EBAG9 EXT1 FAM20B FAM3C GALNT2 GALNT6 GALNT7 GCNT1 GLG1 GLT8D1 GOLIM4 GOLM2 HTT LNX1 MAN1B1 MGAT2 PGAP4 POMGNT1 TPST1 TPST2 ZDHHC17	3 interacting genes: DNM2 GOLPH3 GOLPH3L
Entrez ID		55204	11253
HPRD ID		17048	05068
Ensembl ID		ENSG00000143457	ENSG00000177239
Uniprot IDs		Q9H4A5	H0YG20 Q9UKM7
PDB IDs			1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7
Enriched GO Terms of Interacting Partners?		Golgi Apparatus Golgi Membrane Glycoprotein Metabolic Process Glycosyltransferase Activity Glycoprotein Biosynthetic Process Protein Glycosylation Macromolecule Glycosylation Glycosylation Carbohydrate Derivative Metabolic Process Carbohydrate Derivative Biosynthetic Process Protein O-linked Glycosylation Transferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein Modification Process Protein Metabolic Process Macromolecule Biosynthetic Process Polypeptide N-acetylgalactosaminyltransferase Activity Membrane Proteoglycan Biosynthetic Process Protein-tyrosine Sulfotransferase Activity Carbohydrate Binding Proteoglycan Metabolic Process Macromolecule Metabolic Process Manganese Ion Binding Golgi Cisterna Membrane 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Carbohydrate Metabolic Process Sulfation Acetylglucosaminyltransferase Activity UDP-glycosyltransferase Activity Leukocyte Tethering Or Rolling Golgi Lumen Leukocyte Adhesion To Vascular Endothelial Cell Viral Protein Processing Basement Membrane Organization Bone Morphogenesis Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Peptidyl-tyrosine Sulfation Perforant Pathway To Dendrate Granule Cell Synapse Golgi Stack N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Trans-Golgi Network Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity	Vesicle Budding From Membrane Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Post-Golgi Vesicle-mediated Transport Golgi Cisterna Golgi Vesicle Transport Phosphatidylinositol-4-phosphate Binding Vesicle Organization Golgi To Plasma Membrane Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Membrane Organization Golgi Membrane Histone H3Q5ser Reader Activity Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Membrane Tubulation Vesicle Scission Histone H3K4me1 Reader Activity Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Localization To Plasma Membrane Protein Targeting Establishment Of Protein Localization To Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Vesicle-mediated Transport Positive Regulation Of Protein Transport Membrane Tubulation Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Apparatus Positive Regulation Of Secretion By Cell Protein Localization To Membrane Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization MLL1/2 Complex Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Transferrin Transport
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