MAN1B1

Gene Name		mannosidase, alpha, class 1B, member 1
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Vesicle Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding
	Biological Process	Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) ER Quality Control Compartment (ERQC) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs		1,4-Butanediol Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside Kifunensine Alpha-D-Mannose 1-Deoxynojirimycin
Diseases
GWAS
Protein-protein Interactions		1 interactors: DNM2
Entrez ID		11253
HPRD ID		05068
Ensembl ID		ENSG00000177239
Uniprot IDs		Q9UKM7
PDB IDs		1FMI 1FO2 1FO3 1X9D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Membrane Tubulation Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Transferrin Transport Regulation Of Nitric-oxide Synthase Activity Receptor Internalization Regulation Of Axon Extension Regulation Of Oxidoreductase Activity Iron Ion Transport Receptor Metabolic Process Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport Reactive Oxygen Species Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Size Regulation Of Axonogenesis Establishment Of Vesicle Localization Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Golgi Vesicle Transport Antigen Processing And Presentation Regulation Of Developmental Growth Establishment Of Organelle Localization Regulation Of Cellular Component Size Regulation Of Cell Growth Receptor-mediated Endocytosis
Tagcloud ?		asparagine decapeptide erad eukaryotes fate gatekeeper glycan glycosylation golgi hong initiate kong localizes manifested mannosidase misfolded mns1p necessitating null organelle ortholog participation processed proteostasis removes retention retrieval uncovered vertebrate