MAN1B1 and DNM2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAN1B1	DNM2
Description		mannosidase alpha class 1B member 1	dynamin 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Endoplasmic Reticulum Quality Control Compartment Extracellular Vesicle	Golgi Membrane Phagocytic Cup Uropod Podosome Cytoplasm Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Endomembrane System Postsynaptic Density Membrane Clathrin-coated Vesicle Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Postsynaptic Membrane Recycling Endosome Extracellular Exosome Anchoring Junction Presynapse
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Hydrolase Activity SH3 Domain Binding Enzyme Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Glycoprotein Metabolic Process Oligosaccharide Metabolic Process Viral Protein Processing ERAD Pathway Protein Alpha-1,2-demannosylation Endoplasmic Reticulum Mannose Trimming	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Autophagy Centrosome Cycle Signal Transduction Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Transport Neuron Projection Morphogenesis Protein Polymerization Membrane Organization Actin Filament Bundle Organization Membrane Tubulation Vesicle Scission Negative Regulation Of Membrane Tubulation
Pathways		Defective MAN1B1 causes MRT15 ER Quality Control Compartment (ERQC) Maturation of spike protein	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1
Drugs		1,4-Butanediol Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside Kifunensine Duvoglustat
Diseases			Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Coronary artery aneurysm in Kawasaki disease ( 33772158) Initial alcohol sensitivity ( 30276832)	Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)
Interacting Genes		3 interacting genes: DNM2 GOLPH3 GOLPH3L	74 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CEBPA CTTN DDX39B DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L FXR1 FXR2 GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PCNT PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6
Entrez ID		11253	1785
HPRD ID		05068	03852
Ensembl ID		ENSG00000177239	ENSG00000079805
Uniprot IDs		H0YG20 Q9UKM7	P50570 Q8N1K8
PDB IDs		1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7	2YS1
Enriched GO Terms of Interacting Partners?		Vesicle Budding From Membrane Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Post-Golgi Vesicle-mediated Transport Golgi Cisterna Golgi Vesicle Transport Phosphatidylinositol-4-phosphate Binding Vesicle Organization Golgi To Plasma Membrane Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Membrane Organization Golgi Membrane Histone H3Q5ser Reader Activity Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Membrane Tubulation Vesicle Scission Histone H3K4me1 Reader Activity Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Localization To Plasma Membrane Protein Targeting Establishment Of Protein Localization To Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Vesicle-mediated Transport Positive Regulation Of Protein Transport Membrane Tubulation Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Apparatus Positive Regulation Of Secretion By Cell Protein Localization To Membrane Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization MLL1/2 Complex Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Transferrin Transport	Cytosol Endocytosis Cytoplasm Import Into Cell Cadherin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Vesicle-mediated Transport Identical Protein Binding Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Metabolic Process Regulation Of Endocytosis Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Synaptic Receptor Adaptor Activity Regulation Of Signaling Dendritic Spine Positive Regulation Of Organelle Organization Clathrin-coated Pit Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Proline-rich Region Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Organelle Organization Presynaptic Endocytosis Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Synapse Regulation Of Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Transport Postsynaptic Endocytic Zone Regulation Of Vesicle-mediated Transport Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glutamatergic Synapse Ionotropic Glutamate Receptor Binding
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