MAN1B1 and GOLPH3

Number of citations of the paper that reports this interaction (PubMedID 34473204)
68

Data Source:
BioGRID (pull down)

		MAN1B1	GOLPH3
Description		mannosidase alpha class 1B member 1	golgi phosphoprotein 3
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Endoplasmic Reticulum Quality Control Compartment Extracellular Vesicle	Golgi Membrane Mitochondrion Mitochondrial Intermembrane Space Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Golgi Cisterna Golgi Cisterna Membrane
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Metal Ion Binding	Protein Binding Lipid Binding Enzyme Binding Phosphatidylinositol-4-phosphate Binding Cargo Adaptor Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Glycoprotein Metabolic Process Oligosaccharide Metabolic Process Viral Protein Processing ERAD Pathway Protein Alpha-1,2-demannosylation Endoplasmic Reticulum Mannose Trimming	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Glycoprotein Biosynthetic Process Protein Secretion Gene Expression Regulation Of Mitochondrion Organization Protein Transport Cell Migration Lamellipodium Assembly Positive Regulation Of TOR Signaling Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Protein Retention In Golgi Apparatus Golgi Vesicle Budding Positive Regulation Of Protein Secretion Leukocyte Tethering Or Rolling Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Ribbon Formation Asymmetric Golgi Ribbon Formation Protein Targeting To Golgi Apparatus
Pathways		Defective MAN1B1 causes MRT15 ER Quality Control Compartment (ERQC) Maturation of spike protein
Drugs		1,4-Butanediol Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside Kifunensine Duvoglustat
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 33772158) Initial alcohol sensitivity ( 30276832)	Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: DNM2 GOLPH3 GOLPH3L	23 interacting genes: ARL6IP1 B4GALT4 C1GALT1 CANT1 DIPK2A EBAG9 EXT1 FAM20B FAM3C GALNT2 GALNT6 GALNT7 GCNT1 GLG1 GLT8D1 GOLIM4 GOLM2 MAN1B1 MGAT2 PGAP4 POMGNT1 TPST1 TPST2
Entrez ID		11253	64083
HPRD ID		05068	11007
Ensembl ID		ENSG00000177239	ENSG00000113384
Uniprot IDs		H0YG20 Q9UKM7	Q9H4A6
PDB IDs		1FMI 1FO2 1FO3 1X9D 5KIJ 5KK7	3KN1
Enriched GO Terms of Interacting Partners?		Vesicle Budding From Membrane Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Post-Golgi Vesicle-mediated Transport Golgi Cisterna Golgi Vesicle Transport Phosphatidylinositol-4-phosphate Binding Vesicle Organization Golgi To Plasma Membrane Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Membrane Organization Golgi Membrane Histone H3Q5ser Reader Activity Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Membrane Tubulation Vesicle Scission Histone H3K4me1 Reader Activity Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Localization To Plasma Membrane Protein Targeting Establishment Of Protein Localization To Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Vesicle-mediated Transport Positive Regulation Of Protein Transport Membrane Tubulation Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Apparatus Positive Regulation Of Secretion By Cell Protein Localization To Membrane Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization MLL1/2 Complex Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Transferrin Transport	Golgi Apparatus Golgi Membrane Glycoprotein Metabolic Process Glycosyltransferase Activity Glycoprotein Biosynthetic Process Protein Glycosylation Macromolecule Glycosylation Carbohydrate Derivative Metabolic Process Glycosylation Carbohydrate Derivative Biosynthetic Process Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Transferase Activity Macromolecule Biosynthetic Process Protein Modification Process Protein Metabolic Process Membrane Polypeptide N-acetylgalactosaminyltransferase Activity Proteoglycan Biosynthetic Process Protein-tyrosine Sulfotransferase Activity Carbohydrate Binding Proteoglycan Metabolic Process Macromolecule Metabolic Process Manganese Ion Binding Golgi Cisterna Membrane Carbohydrate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation Acetylglucosaminyltransferase Activity UDP-glycosyltransferase Activity Leukocyte Tethering Or Rolling Golgi Lumen Leukocyte Adhesion To Vascular Endothelial Cell Viral Protein Processing Basement Membrane Organization Bone Morphogenesis Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Golgi Stack Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Peptidyl-tyrosine Sulfation Trans-Golgi Network Protein Homodimerization Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Leukocyte Cell-cell Adhesion
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