NADSYN1 and UPF1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		NADSYN1	UPF1
Gene Name		NAD synthetase 1	UPF1 regulator of nonsense transcripts homolog (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	NAD+ Synthase (glutamine-hydrolyzing) Activity ATP Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds	DNA Binding Chromatin Binding RNA Binding ATP-dependent RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process NAD Biosynthetic Process NAD Metabolic Process Small Molecule Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Gene Expression Histone MRNA Catabolic Process
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Vitamin D insufficiency ( 20541252) Vitamin D levels ( 20418485)
Protein-Protein Interactions		3 interactors: CUTC MYO15B UPF1	31 interactors: ABHD16A ACSS2 ATR CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG GSPT2 HIRA LSM8 NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		55191	5976
HPRD ID		16309	03254
Ensembl ID		ENSG00000172890	ENSG00000005007
Uniprot IDs		B3KUU4 Q6IA69	Q92900
PDB IDs			2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP
Enriched GO Terms of Interacting Partners?		Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Dosage Compensation Histone MRNA Metabolic Process Copper Ion Homeostasis Copper Ion Transport	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process RNA Localization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Surveillance MRNA Transport RNA Transport Gene Expression Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Nitrogen Compound Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Histone MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Metabolic Process Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression Regulation Of Translation RRNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Ribosome Biogenesis Intracellular MRNA Localization RRNA Catabolic Process Positive Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Maturation Of 5.8S RRNA NcRNA Metabolic Process RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Formation Of Translation Preinitiation Complex RRNA Processing
Tagcloud ?		asip atm casp8 ccnd1 color cyp2r1 dark eye firstly gwas irf4 kaspar lately lentigines mc1r mx2 oca2 parp1 penetrance pigmentation predisposition rs12203592 rs1485993 rs1801516 rs3219090 slc45a2 spanish try works	aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Difference) ?		asip atm casp8 ccnd1 color cyp2r1 dark eye firstly gwas irf4 kaspar lately lentigines mc1r mx2 oca2 parp1 penetrance pigmentation predisposition rs12203592 rs1485993 rs1801516 rs3219090 slc45a2 spanish try works	aav9 adeno als amyotrophic cord decay empty exerts forelimb green helps implicate mycupf1 nmd nonsense otherwise paralysis quadriplegic recapitulate reproducible respective spinal tdp titrated transactive twofold upframeshift validate vector
Tagcloud (Intersection) ?