NADSYN1 and CUTC

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NADSYN1	CUTC
Gene Name		NAD synthetase 1	cutC copper transporter
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	NAD+ Synthase (glutamine-hydrolyzing) Activity ATP Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds	Copper Ion Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process NAD Biosynthetic Process NAD Metabolic Process Small Molecule Metabolic Process	Copper Ion Transport Protein Tetramerization Copper Ion Homeostasis
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS		Vitamin D insufficiency ( 20541252) Vitamin D levels ( 20418485)	Crohn's disease ( 22412388) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: CUTC MYO15B UPF1	11 interactors: ASCC2 BCL6 CEP76 LNX1 NADSYN1 NIF3L1 NUDT18 PIM2 SDCBP SLC27A6 SPG21
Entrez ID		55191	51076
HPRD ID		16309	13100
Ensembl ID		ENSG00000172890	ENSG00000119929
Uniprot IDs		B3KUU4 Q6IA69	Q9NTM9
PDB IDs			3IWP
Enriched GO Terms of Interacting Partners?		Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Dosage Compensation Histone MRNA Metabolic Process Copper Ion Homeostasis Copper Ion Transport	GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Dihydrobiopterin Metabolic Process Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process
Tagcloud ?		asip atm casp8 ccnd1 color cyp2r1 dark eye firstly gwas irf4 kaspar lately lentigines mc1r mx2 oca2 parp1 penetrance pigmentation predisposition rs12203592 rs1485993 rs1801516 rs3219090 slc45a2 spanish try works
Tagcloud (Difference) ?		asip atm casp8 ccnd1 color cyp2r1 dark eye firstly gwas irf4 kaspar lately lentigines mc1r mx2 oca2 parp1 penetrance pigmentation predisposition rs12203592 rs1485993 rs1801516 rs3219090 slc45a2 spanish try works
Tagcloud (Intersection) ?