RIC8B and GNAQ

Number of citations of the paper that reports this interaction (PMID 12652642)
15

Data Source:
HPRD (in vitro)

		RIC8B	GNAQ
Gene Name		RIC8 guanine nucleotide exchange factor B	guanine nucleotide binding protein (G protein), q polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Cell Cortex	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways			G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GNAQ GNAS LRP1	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		55188	2776
HPRD ID		16452	02998
Ensembl ID		ENSG00000111785
Uniprot IDs		B7WPL0 Q9NVN3	P50148
PDB IDs
Enriched GO Terms of Interacting Partners?		Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Regulation Of Phospholipase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Post-embryonic Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Post-embryonic Body Morphogenesis Beta-amyloid Clearance Embryonic Limb Morphogenesis Limb Morphogenesis Platelet Activation Limb Development Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Blood Coagulation Hemostasis Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Neuron Remodeling Regulation Of Phospholipase A2 Activity Regulation Of Melanocyte Differentiation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Development Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Positive Regulation Of CAMP-mediated Signaling Regulation Of Body Fluid Levels Wound Healing Maternal Behavior Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Hair Follicle Placode Formation Embryonic Morphogenesis Positive Regulation Of Cholesterol Efflux Cell Surface Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cell Activation Lipoprotein Transport Positive Regulation Of Cholesterol Transport Response To Wounding Negative Regulation Of Multicellular Organism Growth Positive Regulation Of GTPase Activity	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?			adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?			adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?