SLC6A2

Description		solute carrier family 6 member 2
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Synaptic Vesicle Membrane Neuronal Cell Body Membrane Presynaptic Membrane Cell Projection Neuron Projection Synapse
	Molecular Function	Actin Binding Neurotransmitter Transmembrane Transporter Activity Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Symporter Activity Sodium:chloride Symporter Activity Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Response To Xenobiotic Stimulus Monoamine Transport Norepinephrine Transport Sodium Ion Transmembrane Transport Response To Pain Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Uptake Neuron Cellular Homeostasis Catecholamine Uptake Neurotransmitter Reuptake Chloride Transmembrane Transport
Pathways		SLC-mediated transport of neurotransmitters Defective SLC6A2 causes orthostatic intolerance (OI)
Drugs		Amphetamine Phentermine Tramadol Guanadrel Reboxetine Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Methylphenidate Meperidine Imipramine Duloxetine Dextromethorphan Nortriptyline Amoxapine Mazindol Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Cyclobenzaprine Maprotiline Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Ketamine Clomipramine Ephedra sinica root Ephedrine Ginkgo biloba MMDA Midomafetamine Dextroamphetamine Metamfetamine Phendimetrazine Nomifensine Amineptine Debrisoquine Bicifadine Milnacipran XEN-2174 DDP-225 CRx-119 Amitifadine Mianserin Tesofensine Tapentadol Trodusquemine Desvenlafaxine Dexmethylphenidate Levomilnacipran Vortioxetine Dosulepin Viloxazine Zotepine Dasotraline Netarsudil Solriamfetol Serdexmethylphenidate
Diseases		Orthostatic intolerance (OI); Postural tachycardia syndrome (POTS)
GWAS		Birth weight ( 31043758) Post bronchodilator FEV1 ( 26634245)
Novel Interacting Genes		1 novel interacting genes: RPGRIP1L
Interacting Genes		2 interacting genes: PPP2R1A STX1A
Entrez ID		6530
HPRD ID		01232
Ensembl ID		ENSG00000103546
Uniprot IDs		H3BRE9 P23975
PDB IDs		8HFE 8HFF 8HFG 8HFI 8HFL 8I3V 8WGR 8WGX 8WTU 8WTV 8WTW 8WTX 8WTY 8XB2 8XB3 8XB4 8Y8Z 8Y90 8Y91 8Y92 8Y93 8Y94 8Y95 8YR2 8Z1L 8ZOY 8ZP1 8ZP2 8ZPB
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Elongation Myosin Head/neck Binding Thromboxane A2 Receptor Binding Chromosome Separation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion Spindle Elongation Neuron Projection Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Meiotic Sister Chromatid Cohesion, Centromeric Protein Antigen Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Actomyosin Synaptic Vesicle Docking Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion ATP-dependent Protein Binding Regulation Of Synaptic Vesicle Priming Response To Gravity SNARE Complex Assembly Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Chloride Channel Inhibitor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Retinal Rod Cell Development Neural Tube Patterning Pericardium Development Nose Development Lateral Ventricle Development Calcium Channel Inhibitor Activity INTAC Complex FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Cellular Component Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Organelle Organization Glutamatergic Synapse Female Meiotic Nuclear Division Corpus Callosum Development Positive Regulation Of Neurotransmitter Secretion RNA Polymerase II Transcription Initiation Surveillance Establishment Of Planar Polarity Negative Regulation Of Hippo Signaling Myosin Binding Head Development Olfactory Bulb Development Presynaptic Active Zone Membrane Telencephalon Development Embryonic Hindlimb Morphogenesis
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