CENPQ and SIKE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CENPQ	SIKE1
Description		centromere protein Q	suppressor of IKBKE 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Actin Cytoskeleton	Cytoplasm Cytosol FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	Chromosome Segregation Metaphase Chromosome Alignment Positive Regulation Of Protein Localization To Kinetochore	Negative Regulation Of Hippo Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Age at first sexual intercourse ( 34211149)
Interacting Genes		12 interacting genes: AARD ABI2 ABI3 APP BRME1 CENPU EMILIN1 HDAC7 KDM1A PLK1 SIKE1 SNX2	13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C
Entrez ID		55166	80143
HPRD ID		10788	07958
Ensembl ID		ENSG00000031691	ENSG00000052723
Uniprot IDs		Q7L2Z9	Q9BRV8
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis SCAR Complex Actin-based Cell Projection Identical Protein Binding Insulin Receptor Binding Regulation Of Postsynapse Organization Dendritic Spine Neuron Maturation Cell Junction Organization Lamellipodium Regulation Of Lamellipodium Assembly Dendritic Shaft Regulation Of Dendritic Spine Morphogenesis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Epigenetic Regulation Of Gene Expression Regulation Of Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synapse Organization Anatomical Structure Morphogenesis Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Developmental Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Negative Regulation Of Cellular Component Organization Phosphorylation Synaptonemal Complex Disassembly Protein Phosphorylation Nuclear Division Golgi Inheritance Chromosome Regulation Of Double-strand Break Repair Via Homologous Recombination Signaling Adaptor Activity	TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Syntaxin Binding Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore
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