LCMT1

Description		leucine carboxyl methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein C-terminal Leucine Carboxyl O-methyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Methylation C-terminal Protein Methylation Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Protein-containing Complex Assembly Methylation Protein Modification Process Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Cyclin A/B1/B2 associated events during G2/M transition
Drugs		Leucine
Diseases
GWAS		Lead levels ( 26025379)
Interacting Genes		5 interacting genes: BRCA1 CFTR FXR2 PPP2CB TAB1
Entrez ID		51451
HPRD ID		17266
Ensembl ID		ENSG00000205629
Uniprot IDs		Q9UIC8
PDB IDs		3IEI 3O7W 3P71
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Cell Communication Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Regulation Of Signaling Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Serine/threonine Phosphatase Activity Protein-containing Complex Positive Regulation Of Monoatomic Anion Transport Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Centriole Replication Regulation Of Microtubule-based Process BRCA1-A Complex BRCA1-B Complex Embryo Development Ending In Birth Or Egg Hatching Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Multicellular Organism Development BRCA1-C Complex Ubiquitin-modified Histone Reader Activity Response To Indole-3-methanol Response To Alcohol Chordate Embryonic Development Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Neurofibrillary Tangle Assembly Mitogen-activated Protein Kinase P38 Binding Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Gene Expression Amelogenesis Positive Regulation Of Long-term Neuronal Synaptic Plasticity Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Gene Expression Gamma-tubulin Ring Complex Negative Regulation Of Centrosome Duplication Regulation Of Multicellular Organismal Process Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
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