LCMT1

Gene Name		leucine carboxyl methyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity
	Biological Process	Cellular Protein Modification Process Protein Methylation C-terminal Protein Methylation Regulation Of Glucose Metabolic Process Negative Regulation Of Protein Complex Assembly Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways
Drugs		L-Leucine
Diseases
GWAS
Protein-protein Interactions		4 interactors: BRCA1 FXR2 PPP2CB TAB1
Entrez ID		51451
HPRD ID		17266
Ensembl ID		ENSG00000205629
Uniprot IDs		Q9UIC8
PDB IDs		3IEI 3O7W 3P71
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K9 Acetylation Intracellular Receptor Signaling Pathway Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Cellular Response To Stress Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Activation Of MAPKKK Activity Regulation Of Histone H3-K9 Acetylation Regulation Of Gene Expression Cellular Response To Organic Substance Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Regulation Of Protein Metabolic Process Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Cellular Response To Growth Factor Stimulus Postreplication Repair Positive Regulation Of Protein Acetylation Response To Growth Factor Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Organic Substance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Genetic Imprinting Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Vascular Endothelial Growth Factor Production G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation
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