TTK and TUBB1

Number of citations of the paper that reports this interaction (PMID 15304323)
6

Data Source:
HPRD (in vivo)

		TTK	TUBB1
Gene Name		TTK protein kinase	tubulin, beta 1 class VI
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Membrane	Cytoplasm Microtubule Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Spindle Organization Mitotic Spindle Organization Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Chromosome Separation	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Spindle Assembly Protein Polymerization Transmembrane Transport
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Vindesine Paclitaxel Docetaxel Colchicine Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS			Mean platelet volume ( 22139419 22423221)
Protein-Protein Interactions		11 interactors: APP AZU1 CASC5 CDCA8 CDK2 CTD MAPK6 RPS6KA1 TP53 TUBB TUBB1	1 interactors: TTK
Entrez ID		7272	81027
HPRD ID		04973	18243
Ensembl ID		ENSG00000112742	ENSG00000101162
Uniprot IDs		P33981	Q9H4B7
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 4B94 4BHZ 4BI0 4BI1 4BI2 4H7X 4H7Y
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Hydrolase Activity Cell Division Microtubule Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Immune Response Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Nuclear Division Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Neuron Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Fractalkine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Spindle Assembly Regulation Of Mitotic Cell Cycle Chromosome Organization Cellular Component Assembly Protein Complex Assembly Response To Oxidative Stress Blood Coagulation Hemostasis Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Cytoskeleton Organization Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hepatic Stellate Cell Activation Oligodendrocyte Apoptotic Process	Chromosome Separation Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Mitotic Spindle Organization Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Segregation Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Division Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process
Tagcloud ?		amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 sgol1 subtype tumorigenic upregulated	3435tt abcb1 actg1 ala310 capg carriers childhood cyp3a5 disrupt influencing lymphoblastic map4 microtubules mitotic neuropathy neurotoxicity nucleotides polymorphisms rs1135989 rs3770102 rs4728709 seventeen spindle start substitution synonymous variation vcr vincristine
Tagcloud (Difference) ?		amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 sgol1 subtype tumorigenic upregulated	3435tt abcb1 actg1 ala310 capg carriers childhood cyp3a5 disrupt influencing lymphoblastic map4 microtubules mitotic neuropathy neurotoxicity nucleotides polymorphisms rs1135989 rs3770102 rs4728709 seventeen spindle start substitution synonymous variation vcr vincristine
Tagcloud (Intersection) ?