TTK and TUBB1

Number of citations of the paper that reports this interaction (PubMedID 15304323)
0

Data Source:
HPRD (in vivo)

		TTK	TUBB1
Description		TTK protein kinase	tubulin beta 1 class VI
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Spindle Membrane	Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Kinetochore Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding Metal Ion Binding
	Biological Process	Nuclear Division Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Female Meiosis Chromosome Segregation Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Protein Localization To Chromosome Positive Regulation Of SMAD Protein Signal Transduction Nuclear Chromosome Segregation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Protein Localization To Meiotic Spindle Midzone	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Platelet Formation Thyroid Gland Development Microtubule Polymerization Spindle Assembly Thyroid Hormone Transport Platelet Aggregation
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Pyrazolanthrone Fostamatinib BOS172722	Vindesine Paclitaxel Docetaxel Epothilone D Patupilone CYT997 ZEN-012 Cabazitaxel Eribulin Milataxel Phenethyl Isothiocyanate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)	Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean platelet volume ( 22139419 27863252 32888494) Platelet count ( 22423221 32888494 29403010 27863252 24777453) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16	1 interacting genes: TTK
Entrez ID		7272	81027
HPRD ID		04973	18243
Ensembl ID		ENSG00000112742	ENSG00000101162
Uniprot IDs		P33981	Q9H4B7
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND 7CHM 7CHN 7CHT 7CIL 7CJA 7CLH 7LQD
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Cellular Component Assembly Mitotic Cell Cycle Chromosome Organization Cell Division Nuclear Envelope Lumen Protein Tetramerization Regulation Of Mitotic Cell Cycle Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Spindle Assembly Intercellular Bridge Membraneless Organelle Assembly Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Heparan Sulfate Proteoglycan Binding Ubiquitin Protein Ligase Binding Response To Salt Stress Muscle Cell Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Molecular Function Activator Activity Disordered Domain Specific Binding Organelle Assembly Ephrin Receptor Binding Microglial Cell Activation Immune Effector Process Regulation Of Organelle Organization Positive Regulation Of Gene Expression Cytoplasm Spindle Organization Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Protein-containing Complex Assembly Microtubule-based Process Response To Antibiotic Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nitric Oxide Biosynthetic Process Organelle Organization Sister Chromatid Segregation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein-containing Complex Organization	Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Female Meiosis Chromosome Segregation Kinetochore Binding Phosphatidic Acid Transfer Activity Negative Regulation Of Meiotic Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Meiotic Chromosome Segregation Protein Localization To Kinetochore Negative Regulation Of Meiotic Cell Cycle Protein Serine/threonine/tyrosine Kinase Activity Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Intermembrane Lipid Transfer Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Mitotic Nuclear Division Protein Localization To Chromosome, Centromeric Region Protein Localization To Cytoskeleton Nuclear Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Chromosome Organization Regulation Of Chromosome Separation Mitochondrial Intermembrane Space Phospholipid Transport Nuclear Division Mitotic Spindle Organization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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