TTK and AZU1

Number of citations of the paper that reports this interaction (PubMedID 15304323)
0

Data Source:
HPRD (in vivo)

		TTK	AZU1
Description		TTK protein kinase	azurocidin 1
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Spindle Membrane	Extracellular Region Extracellular Space Membrane Azurophil Granule Membrane Azurophil Granule Lumen Azurophil Granule Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Kinetochore Binding Protein Serine Kinase Activity	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Toxic Substance Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Nuclear Division Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Female Meiosis Chromosome Segregation Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Protein Localization To Chromosome Positive Regulation Of SMAD Protein Signal Transduction Nuclear Chromosome Segregation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Protein Localization To Meiotic Spindle Midzone	Microglial Cell Activation Proteolysis Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Glial Cell Migration Antimicrobial Humoral Response Positive Regulation Of Fractalkine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Monocyte Extravasation Monocyte Activation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Cellular Extravasation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Induction Of Positive Chemotaxis Protein Maturation Defense Response To Virus Cell Chemotaxis Neutrophil-mediated Killing Of Bacterium
Pathways			Neutrophil degranulation
Drugs		Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)	Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16	2 interacting genes: CLEC4G TTK
Entrez ID		7272	566
HPRD ID		04973	01221
Ensembl ID		ENSG00000112742	ENSG00000172232
Uniprot IDs		P33981	P20160
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND 7CHM 7CHN 7CHT 7CIL 7CJA 7CLH 7LQD	1A7S 1AE5 1FY1 1FY3
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Cellular Component Assembly Mitotic Cell Cycle Chromosome Organization Cell Division Nuclear Envelope Lumen Protein Tetramerization Regulation Of Mitotic Cell Cycle Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Spindle Assembly Intercellular Bridge Membraneless Organelle Assembly Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Heparan Sulfate Proteoglycan Binding Ubiquitin Protein Ligase Binding Response To Salt Stress Muscle Cell Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Molecular Function Activator Activity Disordered Domain Specific Binding Organelle Assembly Ephrin Receptor Binding Microglial Cell Activation Immune Effector Process Regulation Of Organelle Organization Positive Regulation Of Gene Expression Cytoplasm Spindle Organization Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Protein-containing Complex Assembly Microtubule-based Process Response To Antibiotic Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nitric Oxide Biosynthetic Process Organelle Organization Sister Chromatid Segregation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Protein-containing Complex Organization	Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Virus Coreceptor Activity Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Glycosylated Region Protein Binding Female Meiosis Chromosome Segregation Kinetochore Binding Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation Immature T Cell Proliferation In Thymus Negative Regulation Of Meiotic Cell Cycle Phase Transition Fructose Binding Meiotic Cell Cycle Checkpoint Signaling Carbohydrate Derivative Binding Negative Regulation Of T Cell Differentiation In Thymus Protein Localization To Kinetochore Polysaccharide Binding Regulation Of Immature T Cell Proliferation In Thymus Meiotic Chromosome Segregation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Meiotic Cell Cycle D-mannose Binding Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Viral Life Cycle Protein Serine/threonine/tyrosine Kinase Activity Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition T Cell Mediated Immunity Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Mitotic Nuclear Division Protein Localization To Chromosome, Centromeric Region Pattern Recognition Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Protein Localization To Cytoskeleton Negative Regulation Of Alpha-beta T Cell Activation Nuclear Chromosome Segregation Negative Regulation Of T Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of SMAD Protein Signal Transduction Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process Regulation Of Chromosome Separation Negative Regulation Of T Cell Proliferation T Cell Proliferation Negative Regulation Of Adaptive Immune Response
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