SGO1 and PPP2R5D

Number of citations of the paper that reports this interaction (PubMedID 16541024)
0

Data Source:
HPRD (two hybrid, in vivo)

		SGO1	PPP2R5D
Description		shugoshin 1	protein phosphatase 2 regulatory subunit B'delta
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Kinase Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric	Signal Transduction Nervous System Development Meiotic Sister Chromatid Cohesion
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		21 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC PTPA RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6	18 interacting genes: BUB1B CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DYDC1 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C RORC SGO1 USHBP1
Entrez ID		151648	5528
HPRD ID		12377	09039
Ensembl ID		ENSG00000129810	ENSG00000112640
Uniprot IDs		B5BUA4 Q5FBB7	Q14738
PDB IDs		3FGA 3Q6S 4A0I 7ZJS	8U1X 8U89
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity Meiotic Sister Chromatid Cohesion Chromosome Organization Cytosolic Large Ribosomal Subunit DNA-dependent Protein Kinase Complex Chromosome, Centromeric Region DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Cytosolic Ribosome Sister Chromatid Cohesion Cytosol Cytoplasmic Translation Nucleus Structural Constituent Of Ribosome FAR/SIN/STRIPAK Complex Chromosome DNA End Binding Ku70:Ku80 Complex Ribosome Small-subunit Processome Assembly Cytoplasm Ribonucleoprotein Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein-DNA Complex 5'-deoxyribose-5-phosphate Lyase Activity Response To Gamma Radiation Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Macromolecule Biosynthetic Process Spindle Organization Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ribonucleoprotein Complex Biogenesis Translation U3 SnoRNA Binding Protein Serine/threonine Phosphatase Activity INTAC Complex Spindle Assembly Response To Lead Ion Telomere Maintenance RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Ribosome Biogenesis Hyperosmotic Response RNA Binding Maturation Of LSU-rRNA Telomeric DNA Binding Cellular Response To Gamma Radiation	Circadian Regulation Of Gene Expression Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Circadian Rhythm Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Photoperiodism Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Glucocorticoid Secretion Rhythmic Process Cardiac Right Ventricle Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Sister Chromatid Cohesion Response To Blue Light Determination Of Heart Left/right Asymmetry E-box Binding Cellular Response To Radiation Cardiac Ventricle Formation Photoreceptor Activity Cartilage Morphogenesis Meiotic Sister Chromatid Cohesion Cardiac Chamber Formation Negative Regulation Of Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway DNA Damage Response Kinase Binding Positive Regulation Of Circadian Rhythm Epithelial Tube Morphogenesis Entrainment Of Circadian Clock By Photoperiod Regulation Of DNA Damage Checkpoint Apoptotic Process Involved In Morphogenesis Entrainment Of Circadian Clock Nucleus Signal Transduction In Response To DNA Damage Lipid Storage Chromatin Apoptotic Process Involved In Development Protein Serine/threonine Kinase Activity Negative Regulation Of Lipid Transport FAD Binding Protein Dimerization Activity Regulation Of Cell Cycle Phase Transition Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nuclear Receptor Binding Photoreactive Repair RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Heart Tube Formation
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