SGOL1 and PPP2R5B

Number of citations of the paper that reports this interaction (PMID 16541025)
118

Data Source:
HPRD (in vivo)

		SGOL1	PPP2R5B
Gene Name		shugoshin-like 1 (S. pombe)	protein phosphatase 2, regulatory subunit B, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Spindle Pole Nucleoplasm Cytoplasm Centrosome Cytosol Mitotic Cohesin Complex	Protein Phosphatase Type 2A Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding Kinase Binding	Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division	Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt XBP1(S) activates chaperone genes M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated IRE1alpha activates chaperones RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade Unfolded Protein Response (UPR) truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		21 interactors: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET UBC XRCC5 XRCC6	6 interactors: AXIN1 CHEK2 IER3 MAPK1 PPP2CA SGOL1
Entrez ID		151648	5526
HPRD ID		12377	09038
Ensembl ID		ENSG00000129810	ENSG00000068971
Uniprot IDs		B5BUA4 Q5FBB7	Q15173
PDB IDs		3FGA 3Q6S 4A0I
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Viral Life Cycle Viral Transcription Protein Complex Disassembly SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Catabolic Process Aromatic Compound Catabolic Process Protein Localization To Endoplasmic Reticulum Translational Termination MRNA Metabolic Process Protein Targeting To Membrane Membrane Organization Translational Elongation Cellular Protein Complex Disassembly Positive Regulation Of Type I Interferon Production Double-strand Break Repair Via Nonhomologous End Joining Cellular Hyperosmotic Salinity Response Establishment Of Protein Localization To Membrane Translational Initiation Mitotic Cell Cycle Regulation Of Type I Interferon Production Cellular Response To X-ray Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Establishment Of Protein Localization To Organelle Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Membrane Programmed Cell Death Mitotic Cell Cycle Process Cell Death Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cytoplasmic Transport Cellular Response To Stress Establishment Of Integrated Proviral Latency Cellular Response To Fibroblast Growth Factor Stimulus Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Response To Fibroblast Growth Factor Cellular Hyperosmotic Response Hyperosmotic Salinity Response Protein Targeting	Apoptotic Process Programmed Cell Death Cell Death Regulation Of Protein Catabolic Process Death Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Mitotic Cell Cycle Process Mitotic Cell Cycle Intracellular Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Cell Cycle Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Microtubule Cytoskeleton Organization Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Cellular Response To Stress Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Transferase Activity Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Signal Transduction Involved In Intra-S DNA Damage Checkpoint Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Mitotic DNA Integrity Checkpoint Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of DNA Replication MAPK Import Into Nucleus Regulation Of Protein Stability Positive Regulation Of Protein Phosphorylation Activation Of MAPK Activity Mesoderm Development Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity DNA Damage Checkpoint Microtubule-based Process Regulation Of Kinase Activity Mitotic Cell Cycle Checkpoint Fibroblast Growth Factor Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Cellular Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation
Tagcloud ?		amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 subtype ttk tumorigenic upregulated	actb ap1s1 api5 calculating crossbred csn1s2 fabp3 gilts icg lactation ltf mined mrpl39 mtg1 normalization parturition pcsk2 primiparous ptbp1 qpcr qtrt1 rps15a scd tmem24 trim41 underscore uxt vabp vapb
Tagcloud (Difference) ?		amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 subtype ttk tumorigenic upregulated	actb ap1s1 api5 calculating crossbred csn1s2 fabp3 gilts icg lactation ltf mined mrpl39 mtg1 normalization parturition pcsk2 primiparous ptbp1 qpcr qtrt1 rps15a scd tmem24 trim41 underscore uxt vabp vapb
Tagcloud (Intersection) ?