AGGF1 and DHX15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGGF1	DHX15
Description		angiogenic factor with G-patch and FHA domains 1	DEAH-box helicase 15
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus Nuclear Speck U2-type Post-mRNA Release Spliceosomal Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Identical Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Angiogenesis Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Cell Differentiation Positive Regulation Of Angiogenesis	MRNA Splicing, Via Spliceosome Immune System Process MRNA Processing RNA Splicing Response To Toxic Substance Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		Signaling by BRAF and RAF1 fusions	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Myopia (pathological) ( 23049088) Pulmonary emphysema ( 24383474) Sense of smell ( 26632684)
Interacting Genes		12 interacting genes: BLOC1S6 CCDC85B CHERP DHX15 FBXO28 IDH1 MAB21L3 MCRS1 RNF10 SNRPC TNFSF12 TOE1	23 interacting genes: AGGF1 APBB1 CAMSAP3 CEBPA DDX42 DYSF FXR1 GPANK1 KRT75 NKAP NKRF PIN1 PRPF40A PTEN PTP4A2 SPOP TRA2A UBC USP7 WBP4 YWHAB YWHAG ZGPAT
Entrez ID		55109	1665
HPRD ID		07621	04553
Ensembl ID		ENSG00000164252	ENSG00000109606
Uniprot IDs		Q8N302	O43143
PDB IDs			5XDR 6ID1 6SH6 6SH7 8EJM 8RO2
Enriched GO Terms of Interacting Partners?			Nucleic Acid Binding Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Nucleoplasm Negative Regulation Of Metabolic Process Nucleus Ubiquitin Ligase Activator Activity Negative Regulation Of Protein Metabolic Process RNA Binding MRNA Cis Splicing, Via Spliceosome Proline-rich Region Binding Protein Stabilization U2-type Prespliceosome Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Proliferation Regulation Of Protein Metabolic Process Dentate Gyrus Development Negative Regulation Of Phosphorylation Granulocyte Differentiation Molecular Function Inhibitor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Stability Cis-trans Isomerase Activity Phosphoprotein Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Phosphate Metabolic Process Monocyte Activation Involved In Immune Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Phosphorylation Protein Sequestering Activity
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