SLFN12 and JMJD6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SLFN12	JMJD6
Description		schlafen family member 12	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Nuclease Activity Protein Binding Hydrolase Activity Ribosome Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity
	Biological Process	RRNA Catabolic Process Apoptotic Signaling Pathway	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly
Pathways			HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS			Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		4 interacting genes: JMJD6 SUV39H1 TRIM55 TRIM63	30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		55106	23210
HPRD ID		08543	05371
Ensembl ID		ENSG00000172123	ENSG00000070495
Uniprot IDs		Q8IYM2	B2WTI3 B2WTI4 Q6NYC1
PDB IDs		7EG0 7EG1 7EG4 7LRC 7LRD 7LRE	3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?		Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Histone H3K9 Trimethyltransferase Activity ENoSc Complex Transferase Activity Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Cyclin K-CDK12 Complex Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Cytotoxic T Cell Pyroptotic Cell Death Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Defense Response To Symbiont RDNA Heterochromatin Defense Response To Other Organism Skeletal Muscle Atrophy Histone H3K9me2 Methyltransferase Activity RDNA Heterochromatin Formation RNA Processing Oxidative Demethylation Peptidyl-lysine Hydroxylation Recognition Of Apoptotic Cell Cyclin/CDK Positive Transcription Elongation Factor Complex Wide Pore Channel Activity Diapedesis Skeletal Muscle Adaptation Striated Muscle Atrophy Regulation Of Transcription By Glucose Muscle Atrophy Histone H3K9 Methyltransferase Activity Chromatin Silencing Complex Demethylation Transcription Regulator Activator Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Nuclear Lamina Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei Phagocytosis, Recognition Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Other Organism Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Titin Binding Contractile Muscle Fiber Protein Hydroxylation	Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus
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