SLFN12

Description		schlafen family member 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Nuclease Activity Protein Binding Hydrolase Activity Ribosome Binding
	Biological Process	RRNA Catabolic Process Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Novel Interacting Genes		2 novel interacting genes: CDK12 GSDMB
Interacting Genes		4 interacting genes: JMJD6 SUV39H1 TRIM55 TRIM63
Entrez ID		55106
HPRD ID		08543
Ensembl ID		ENSG00000172123
Uniprot IDs		Q8IYM2
PDB IDs		7EG0 7EG1 7EG4 7LRC 7LRD 7LRE
Enriched GO Terms of Interacting Partners?		Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Histone H3K9 Trimethyltransferase Activity ENoSc Complex Transferase Activity Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Cyclin K-CDK12 Complex Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Cytotoxic T Cell Pyroptotic Cell Death Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Defense Response To Symbiont RDNA Heterochromatin Defense Response To Other Organism Skeletal Muscle Atrophy Histone H3K9me2 Methyltransferase Activity RDNA Heterochromatin Formation RNA Processing Oxidative Demethylation Peptidyl-lysine Hydroxylation Recognition Of Apoptotic Cell Cyclin/CDK Positive Transcription Elongation Factor Complex Wide Pore Channel Activity Diapedesis Skeletal Muscle Adaptation Striated Muscle Atrophy Regulation Of Transcription By Glucose Muscle Atrophy Histone H3K9 Methyltransferase Activity Chromatin Silencing Complex Demethylation Transcription Regulator Activator Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Nuclear Lamina Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei Phagocytosis, Recognition Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Other Organism Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Titin Binding Contractile Muscle Fiber Protein Hydroxylation
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