UBE2Q1 and IRF2BPL

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2Q1	IRF2BPL
Description		ubiquitin conjugating enzyme E2 Q1	interferon regulatory factor 2 binding protein like
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Filopodium Cell Projection	Extracellular Space Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Suckling Behavior Embryo Implantation Mating Behavior Fertilization Protein Ubiquitination Reproductive System Development Prolactin Secretion	Negative Regulation Of Transcription By RNA Polymerase II Nervous System Development Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Development Of Secondary Female Sexual Characteristics
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798)	Adverse response to lamotrigine and phenytoin ( 22379998) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Atrial fibrillation ( 29892015 30061737) Feeling nervous ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
Interacting Genes		13 interacting genes: ECPAS FHL3 IRF2BPL ITCH LMNA MDM2 OGT RNF26 RNF31 RNF7 STUB1 TP53 UBC	3 interacting genes: HCK TSG101 UBE2Q1
Entrez ID		55585	64207
HPRD ID		15601	10713
Ensembl ID		ENSG00000160714	ENSG00000119669
Uniprot IDs		Q7Z7E8	Q9H1B7
PDB IDs		2QGX	2CS3
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Regulation Of Programmed Necrotic Cell Death Post-translational Protein Modification Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Cellular Response To Actinomycin D Catabolic Process Regulation Of Necroptotic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Communication Negative Regulation Of Signaling NEDD8 Ligase Activity Response To Actinomycin D Protein Metabolic Process Macromolecule Catabolic Process Cellular Response To Oxygen Levels Cellular Response To UV-C Transferase Activity Proteasomal Protein Catabolic Process Protein Autoubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Antibiotic Negative Regulation Of Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Response To UV-C Response To Hypoxia Nucleoplasm Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Response To Decreased Oxygen Levels Negative Regulation Of Defense Response To Virus Response To Stress Response To Oxygen Levels Negative Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Protein Catabolic Process	Regulation Of Peptidyl-tyrosine Phosphorylation Secretion By Cell Secretion Transport Vesicle Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Maturation Protein Tyrosine Kinase Activity Respiratory Burst After Phagocytosis Leukocyte Migration Involved In Immune Response Exocytosis Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Prolactin Secretion Fibroblast Growth Factor Receptor Activity Regulation Of Organelle Assembly Regulation Of Extracellular Exosome Assembly ATP Binding Endochondral Bone Growth Positive Regulation Of Lipase Activity Respiratory Burst Involved In Defense Response Regulation Of Endocytosis Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Virion Binding Suckling Behavior ESCRT I Complex Nucleotide Binding Chondrocyte Proliferation Regulation Of Protein Phosphorylation Focal Adhesion Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Transferase Activity Type II Interferon-mediated Signaling Pathway Regulation Of Podosome Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Exosomal Secretion Bone Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Binding Protein Kinase Activity Positive Regulation Of Cellular Component Biogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Respiratory Burst Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Exosomal Secretion Viral Budding Via Host ESCRT Complex
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