PPP1R3A and PLN

Number of citations of the paper that reports this interaction (PubMedID 9845327)
0

Data Source:
HPRD (in vivo, in vitro)

		PPP1R3A	PLN
Description		protein phosphatase 1 regulatory subunit 3A	phospholamban
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GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex Phospholamban Complex
	Molecular Function	Protein Phosphatase 1 Binding Glycogen Binding	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding ATPase Binding Transporter Inhibitor Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process	Acrosome Assembly Regulation Of The Force Of Heart Contraction Calcium Ion Transport Intracellular Calcium Ion Homeostasis Notch Signaling Pathway Spermatogenesis Blood Circulation Regulation Of Heart Contraction Visual Learning Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Insulin Response To Testosterone Locomotor Rhythm Negative Regulation Of Heart Contraction Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Circadian Sleep/wake Cycle, Sleep Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Import Regulation Of Relaxation Of Muscle Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways			Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure (smoking interaction) ( 25189868) Chronotype ( 30696823) Hand grip strength ( 29691431) Schizophrenia ( 28991256 30285260) Walking pace ( 33128006)	Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 19305408 19305409 19587794 23166209 24952745 29874175) Resting heart rate ( 27798624)
Interacting Genes		8 interacting genes: PLN PPP1CB PPP1CC PPP1R11 PPP1R7 RPS6KA1 UBXN2B VCP	68 interacting genes: AQP6 ARL13B ARLN ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELN ELOVL4 ERGIC3 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35H1 SLC39A2 SLC61A1 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2
Entrez ID		5506	5350
HPRD ID		02950	01395
Ensembl ID		ENSG00000154415	ENSG00000198523
Uniprot IDs		Q16821	P26678 Q5R352
PDB IDs		5ZQV	1PLP 1ZLL 2HYN 6Y40 7E0Z 7E11 7E12
Enriched GO Terms of Interacting Partners?		PTW/PP1 Phosphatase Complex Circadian Rhythm Photoperiodism Entrainment Of Circadian Clock Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Rhythmic Process Intracellular Signaling Cassette Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Intracellular Signal Transduction Response To Light Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Glycogen Metabolic Process Protein Modification Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Circadian Regulation Of Gene Expression Phosphatase Activity Protein Metabolic Process Myosin-light-chain-phosphatase Activity Flavin Adenine Dinucleotide Catabolic Process Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Response To Radiation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Phosphatase Binding VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Negative Regulation Of Protein Localization To Centrosome Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Circadian Rhythm Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Involved In Mitosis Circadian Sleep/wake Cycle Process Myosin Phosphatase Activity Phosphoprotein Phosphatase Activity Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm Protein Quality Control BAT3 Complex Binding Phosphate-containing Compound Metabolic Process ATPase Inhibitor Activity	Membrane Endoplasmic Reticulum Membrane Protein Binding Sarcoplasmic Reticulum Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Import Into Sarcoplasmic Reticulum Glutathione Peroxidase Activity Leukotriene-C4 Synthase Activity Regulation Of Cardiac Conduction Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
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