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PPP1CB and SH2D4A
Number of citations of the paper that reports this interaction (PMID
17353931
)
246
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
PPP1CB
SH2D4A
Gene Name
protein phosphatase 1, catalytic subunit, beta isozyme
SH2 domain containing 4A
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Nucleus
Nucleoplasm
Nucleolus
Focal Adhesion
Glycogen Granule
Extracellular Vesicular Exosome
MLL5-L Complex
PTW/PP1 Phosphatase Complex
Cytoplasm
Molecular Function
Protein Binding
Phosphatase Activity
Myosin Phosphatase Activity
Protein Kinase Binding
Metal Ion Binding
Myosin-light-chain-phosphatase Activity
Protein Binding
Phosphatase Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Protein Dephosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Triglyceride Catabolic Process
Regulation Of Cell Adhesion
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Small Molecule Metabolic Process
Cell Division
Negative Regulation Of Phosphatase Activity
Pathways
Loss of Function of TGFBR2 in Cancer
Metabolism of lipids and lipoproteins
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
G2/M Transition
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Regulation of PLK1 Activity at G2/M Transition
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Lipid digestion, mobilization, and transport
Cell Cycle, Mitotic
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Mitotic G2-G2/M phases
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
AURKA
BRCA1
CSRNP2
NONO
PPP1R12B
PPP1R12C
PPP1R16A
PPP1R2P3
PPP1R3C
PPP1R9B
PRKAR2A
PTK2
RB1
SH2D4A
TLX1
TP53BP2
WBP11
ZFYVE9
43 interactors:
ALAS1
CASK
CCDC172
CDR2
CEP70
CEP76
DBNL
FSD2
GOLGA2
GRB2
HCLS1
HMBOX1
IKZF1
KRT40
LDOC1
LZTS2
MAGEA11
MAGEA6
MTUS2
NECAB2
NINL
NUTM1
PDE4DIP
PNMA1
PPP1CB
PSTPIP1
RINT1
SH3GL1
SKAP1
SORBS2
SORBS3
SPAG5
STAM2
STX11
TACC1
TFIP11
TRAF2
TRIM23
TRIM27
UBXN11
USHBP1
VPS52
ZBTB16
Entrez ID
5500
63898
HPRD ID
11792
08340
Ensembl ID
ENSG00000213639
ENSG00000104611
Uniprot IDs
P62140
Q9H788
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Negative Regulation Of Catalytic Activity
Negative Regulation Of Cell Cycle
Regulation Of Phosphorus Metabolic Process
Regulation Of Phosphatase Activity
Regulation Of Signaling
Regulation Of Metabolic Process
Regulation Of Mitotic Nuclear Division
Regulation Of Dephosphorylation
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Energy Reserve Metabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Cell Cycle
Microtubule Cytoskeleton Organization
Regulation Of Signal Transduction
Cellular Response To Organonitrogen Compound
Regulation Of Organelle Organization
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Positive Regulation Of Protein Catabolic Process
Apoptotic Process
Androgen Receptor Signaling Pathway
Positive Regulation Of Mitotic Nuclear Division
Programmed Cell Death
Positive Regulation Of Cell Cycle Process
Cell Cycle Process
Cell Death
Death
Regulation Of Centrosome Cycle
Centrosome Cycle
Positive Regulation Of Cellular Protein Metabolic Process
Cytoskeleton Organization
Regulation Of Cell Division
Neuron Differentiation
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Metabolic Process
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Spindle Checkpoint
Regulation Of Lipid Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Phosphatase Activity
Glycogen Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Cell Cycle
Positive Regulation Of Protein Metabolic Process
Regulation Of Lipid Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Cell Cycle
Positive Regulation Of NK T Cell Differentiation
G2/M Transition Of Mitotic Cell Cycle
Organelle Organization
Regulation Of Cytoskeleton Organization
Positive Regulation Of Granulocyte Differentiation
Mitotic Cell Cycle
Immune System Process
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Cell Division
Mitotic Cell Cycle Process
Positive Regulation Of Cell-cell Adhesion
Protein Complex Assembly
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Calcium Ion Import
Actin Filament Organization
Regulation Of T Cell Activation
Cytoskeleton Organization
Positive Regulation Of Cell Activation
Protein K63-linked Ubiquitination
Protein Trimerization
Cellular Protein Complex Assembly
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Regulation Of Microtubule-based Process
Positive Regulation Of Neutrophil Differentiation
Spliceosomal Complex Disassembly
Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Positive Regulation Of Alpha-beta T Cell Differentiation
Regulation Of Immune System Process
Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Actin Filament Polymerization
Positive Regulation Of Cellular Metabolic Process
Regulation Of Lymphocyte Activation
Negative Regulation Of ERBB Signaling Pathway
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Positive Regulation Of Myeloid Leukocyte Differentiation
Regulation Of Cellular Localization
Cell Cycle Process
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Tagcloud
?
3xflag
atp5c1
compatible
created
creating
ddost
deleted
dissociated
envelope
immunolocalization
knock
mammals
persists
phosphatases
reciprocal
sbp
sedimentation
spermatogenesis
spermatogenic
splice
tagged
tandem
testis
ubiquitously
Tagcloud (Difference)
?
3xflag
atp5c1
compatible
created
creating
ddost
deleted
dissociated
envelope
immunolocalization
knock
mammals
persists
phosphatases
reciprocal
sbp
sedimentation
spermatogenesis
spermatogenic
splice
tagged
tandem
testis
ubiquitously
Tagcloud (Intersection)
?