PPP1CB and PPP1R9B

Number of citations of the paper that reports this interaction (PMID 10194355)
28

Data Source:
BioGRID (pull down)

		PPP1CB	PPP1R9B
Gene Name		protein phosphatase 1, catalytic subunit, beta isozyme	protein phosphatase 1, regulatory subunit 9B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Focal Adhesion Glycogen Granule Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Lamellipodium Filopodium Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Synapse
	Molecular Function	Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Cell Adhesion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Filopodium Assembly Regulation Of Synaptic Transmission Cellular Response To Morphine Regulation Of Opioid Receptor Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Metabolism of lipids and lipoproteins Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer G2/M Transition TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Regulation of PLK1 Activity at G2/M Transition Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Mitotic G2-G2/M phases SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AURKA BRCA1 CSRNP2 NONO PPP1R12B PPP1R12C PPP1R16A PPP1R2P3 PPP1R3C PPP1R9B PRKAR2A PTK2 RB1 SH2D4A TLX1 TP53BP2 WBP11 ZFYVE9	23 interactors: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1
Entrez ID		5500	84687
HPRD ID		11792	04506
Ensembl ID		ENSG00000213639	ENSG00000108819
Uniprot IDs		P62140	D3DTX6 Q96SB3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Dephosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Protein Catabolic Process Apoptotic Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Programmed Cell Death Positive Regulation Of Cell Cycle Process Cell Cycle Process Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cell Division Neuron Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Spindle Checkpoint Regulation Of Lipid Kinase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Glycogen Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Energy Reserve Metabolic Process Adrenergic Receptor Signaling Pathway Regulation Of Signaling Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cell Communication Negative Regulation Of Signaling Regulation Of MAPK Cascade Generation Of Precursor Metabolites And Energy Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Triglyceride Catabolic Process Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Receptor Transactivation Acylglycerol Catabolic Process Developmental Process Negative Regulation Of Epinephrine Secretion Response To External Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Glycogen Catabolic Process G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Norepinephrine Secretion Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Muscle System Process Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Localization Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity System Development Anatomical Structure Development Regulation Of Norepinephrine Secretion Negative Regulation Of Signal Transduction Response To Abiotic Stimulus
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Intersection) ?