SLC41A3 and PLP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC41A3	PLP1
Description		solute carrier family 41 member 3	proteolipid protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Membrane	Plasma Membrane Membrane Myelin Sheath Synapse
	Molecular Function	Protein Binding Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Magnesium:sodium Antiporter Activity	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transmembrane Transport Mitochondrial Magnesium Ion Transmembrane Transport	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development
Pathways
Drugs
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Bell's palsy ( 33602968)
Interacting Genes		17 interacting genes: APP ARLN CCL3L3 CCR2 CREB3 GPR37 IGFBP5 MAPK6 NHERF4 NPSR1 PLP1 REL SMCO4 SMO SUFU TMBIM6 TSPO2	91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		54946	5354
HPRD ID		11580	02321
Ensembl ID		ENSG00000114544	ENSG00000123560
Uniprot IDs		Q96GZ6	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs			2XPG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Monocyte Chemotaxis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Signal Transduction Positive Regulation Of Locomotion Locomotion Regulation Of Signal Transduction Spinal Cord Dorsal/ventral Patterning Regulation Of Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Astrocyte Activation Neuropeptide Receptor Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Migration Chemotaxis Regulation Of Metal Ion Transport Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Locomotion Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Endoplasmic Reticulum Positive Regulation Of Leukocyte Migration G Protein-coupled Receptor Activity Hair Follicle Morphogenesis Regulation Of Protein Localization To Nucleus Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Dendrite Amylin Binding Positive Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of T Cell Migration Positive Regulation Of Signal Transduction Dendrite Development	Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity
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