RPP25 and PDLIM7

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RPP25	PDLIM7
Name		ribonuclease P/MRP subunit p25	PDZ and LIM domain 7
Structure
GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex Centriolar Satellite	Stress Fiber Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Nucleic Acid Binding RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	TRNA 5'-leader Removal RRNA Processing TRNA Processing	Ossification Receptor-mediated Endocytosis Heart Development Actin Cytoskeleton Organization Cell Differentiation Muscle Structure Development
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	RET signaling
GWAS		Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Myocardial infarction ( 33532862 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )	Coronary artery disease ( 29212778 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		22 interacting genes: ABI2 BACH2 BANP DDI1 HOMEZ KRT15 LDOC1 LRRC73 PDLIM7 PICK1 PNMA1 POP1 POP4 POP5 POP7 RBPMS RPP14 RPP38 SAT1 SF3B4 TERF2IP ZNF438	63 interacting genes: ABI2 AP5B1 ATOSB BAG3 BSG CATSPER1 CCDC185 DDX6 DGCR6 DNER ENKD1 FAM90A1 FNDC11 FRS3 GARIN6 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SNCA SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		54913	9260
HPRD ID		15276	10436
Ensembl ID		ENSG00000178718	ENSG00000196923
Uniprot IDs		Q9BUL9	Q9NR12
PDB IDs		6AHR 6AHU 6CWX 6LT7	2Q3G 7RM8
GO Terms Enriched among Interactors		Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex Nucleolar Ribonuclease P Complex Ribonuclease P Complex TRNA Processing TRNA Metabolic Process Nucleolus RNA Processing Nucleoplasm RNA Binding RRNA Processing Nucleus RRNA Metabolic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Spermidine Binding RNA Metabolic Process Primary Adaptive Immune Response Involving T Cells And B Cells Spermidine Acetylation Putrescine Catabolic Process Zonula Adherens Assembly Nucleic Acid Metabolic Process Negative Regulation Of DNA Recombination At Telomere Primary Adaptive Immune Response	Protein Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Striated Muscle Cell Apoptotic Process Cellular Response To Actinomycin D Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Muscle Cell Apoptotic Process Response To Actinomycin D Protein Kinase C Signaling Cellular Response To UV-C Regulation Of MAPK Cascade Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Transport Regulation Of Protein Metabolic Process Regulation Of Chaperone-mediated Autophagy Regulation Of Programmed Cell Death Histone H3K36me3 Reader Activity Actin Filament Apoptotic Process Regulation Of Gene Expression Cytoplasmic Side Of Plasma Membrane Supramolecular Fiber Organization Negative Regulation Of Catabolic Process Enzyme Binding Programmed Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Cellular Response To Antibiotic Cell Death Negative Regulation Of Programmed Cell Death Mitotic Nuclear Membrane Disassembly Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding CD40 Receptor Complex