TTC19 and TBX2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TTC19	TBX2
Name		tetratricopeptide repeat domain 19	T-box transcription factor 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Centrosome Membrane Midbody	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Muscle Cell Fate Determination Regulation Of Heart Contraction Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Response To Retinoic Acid Embryonic Heart Tube Development Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Pigment Metabolic Process Involved In Pigmentation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation Roof Of Mouth Development Pharyngeal System Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Developmental Growth Involved In Morphogenesis Mammary Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Cellular Response To Dexamethasone Stimulus Ureteric Peristalsis Cochlea Morphogenesis Cellular Senescence Melanocyte Proliferation Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation Positive Regulation Of Cell Cycle G1/S Phase Transition Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cellular Senescence
Pathways		Complex III assembly	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	None
GWAS		No GWAS studies recorded	Age-related hearing impairment ( 34108613 ) Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Chloride levels ( 29403010 ) Chronic kidney disease ( 20383146 ) Circulating fibroblast growth factor 23 levels ( 30217807 ) Corneal hysteresis ( 32716492 ) Corneal resistance factor ( 32716492 ) Coronary artery disease ( 29212778 ) Creatinine levels ( 31015462 20383145 ) Diastolic blood pressure ( 30487518 27618448 27618447 27841878 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 19893584 18391951 20881960 ) Hypertension ( 30487518 27618447 ) Kidney volume ( 34128465 ) Mean arterial pressure ( 27618448 30487518 26390057 ) Potassium levels ( 29403010 ) Pulse pressure ( 27841878 27618447 ) Refractive error ( 32231278 ) Sitting height ratio ( 25865494 ) Spontaneous preterm birth without premature rupture of membranes ( 31194736 ) Systolic blood pressure ( 30487518 28739976 27618447 27618448 27841878 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		44 interacting genes: AGXT APRT ATXN1 CCDC33 CHMP4A CIMIP1 COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC67A1-AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688	12 interacting genes: ATXN1L CEBPE CIDEB CNOT2 CYSRT1 KRTAP6-3 LMO2 LZTR1 MEIS2 NKX2-5 TNPO2 TTC19
Entrez ID		54902	6909
HPRD ID		07899	02850
Ensembl ID		ENSG00000011295	ENSG00000121068
Uniprot IDs		Q6DKK2	Q13207
PDB IDs		Not available	Not available