TTC19 and APRT

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TTC19	APRT
Name		tetratricopeptide repeat domain 19	adenine phosphoribosyltransferase
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Centrosome Membrane Midbody	Extracellular Region Nucleoplasm Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Adenine Binding Adenine Phosphoribosyltransferase Activity Protein Binding AMP Binding Transferase Activity Glycosyltransferase Activity Heterocyclic Compound Binding
	Biological Process	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Cell Division	Purine Ribonucleoside Salvage Adenine Salvage Grooming Behavior GMP Salvage IMP Salvage AMP Salvage Adenine Metabolic Process
Pathways		Complex III assembly	Neutrophil degranulation Purine salvage Defective APRT disrupts adenine salvage
Drugs		None	Adenine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5H-pyrrolo[3,2-d]pyrimidin-4-amine Citric acid
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Adenine phosphoribosyltransferase deficiency; 2,8-Dihydroxyadenine urolithiasis
GWAS		No GWAS studies recorded	Hair color ( 26926045 )
Novel Interactors		1 novel interactors: ALK	None recorded
Interacting Genes		44 interacting genes: AGXT APRT ATXN1 CCDC33 CHMP4A CIMIP1 COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC67A1-AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688	5 interacting genes: APP IKBKG MLH1 SUMO2 TTC19
Entrez ID		54902	353
HPRD ID		07899	00029
Ensembl ID		ENSG00000011295	ENSG00000198931
Uniprot IDs		Q6DKK2	P07741
PDB IDs		Not available	1ORE 1ZN7 1ZN8 1ZN9 4X44 4X45 6FCH 6FCI 6FCL 6FD4 6FD5 6FD6 6HGP 6HGQ 6HGR 6HGS
GO Terms Enriched among Interactors		None	Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Cell Activation Involved In Immune Response Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Linear Polyubiquitin Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Protein Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Guanine/thymine Mispair Binding Homologous Chromosome Segregation