TTC19 and SHISA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTC19	SHISA6
Description		tetratricopeptide repeat domain 19	shisa family member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Centrosome Membrane Midbody	Postsynaptic Density Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Asymmetric, Glutamatergic, Excitatory Synapse
	Molecular Function	Protein Binding	Protein Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Cell Division	Spermatogenesis Wnt Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Canonical Wnt Signaling Pathway Postsynaptic Neurotransmitter Receptor Diffusion Trapping Excitatory Chemical Synaptic Transmission Regulation Of AMPA Glutamate Receptor Clustering
Pathways		Complex III assembly
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Adventurousness ( 30643258) Copper levels ( 26025379) Daytime sleep phenotypes ( 27126917) Myopia ( 27182965) Obesity-related traits ( 23251661) Refractive error ( 23396134 32231278) Seborrheic dermatitis ( 29203360) Sleep duration (short sleep) ( 30846698) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		44 interacting genes: AGXT APRT ATXN1 CCDC33 CHMP4A CIMIP1 COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC67A1-AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688	29 interacting genes: ANKS1A ARMC7 BAG3 CARD9 CCDC57 CDKN1A CIAO1 CTBP2 CYSRT1 EXOSC5 FBLIM1 GOLGA2 HSF2BP KAT5 KIF9 KIFC3 KRT31 KRTAP3-3 LMO3 NEDD4 OIP5 PFDN5 PLEKHG4 SMARCD1 TLE5 TRIP6 TSSK3 TTC19 UBASH3A
Entrez ID		54902	388336
HPRD ID		07899	13507
Ensembl ID		ENSG00000011295	ENSG00000188803
Uniprot IDs		Q6DKK2	Q6ZSJ9
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Aggrephagy
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