MFSD6 and ALG8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MFSD6	ALG8
Description		major facilitator superfamily domain containing 6	ALG8 alpha-1,3-glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
Pathways			Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31015462) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494)	Depression in smokers ( 30219690) Femur bone mineral density x serum urate levels interaction ( 34046847) Tourette syndrome ( 30818990)
Interacting Genes		37 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 FAM209A GJA8 GJB2 GPR152 GPR42 GPX8 LY6E NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SLC60A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		54842	79053
HPRD ID		13369	10480
Ensembl ID		ENSG00000151690	ENSG00000159063
Uniprot IDs		B7Z7Y2 Q6ZSS7	A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Gap Junction-mediated Intercellular Transport
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